ReviewThe ISME journal2012
An additional step in the transmission of Yersinia pestis?
Review in The ISME journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Retracing the path of evolution: polymorphisms ofEmerging microbes & infections · 2025Article
- Interaction of Bacteria and Fleas, Focusing on the Plague Bacterium-A Review.Microorganisms · 2025Review
- Multiplex PCR System for the Diagnosis of Plague.Current molecular medicine · 2025Review
- Exploring and Mitigating Plague for One Health Purposes.Current tropical medicine reports · 2022Article
- Heightened Virulence ofInfection and immunity · 2021Article
- The roles of environmental variation and parasite survival in virulence-transmission relationships.Royal Society open science · 2021Review
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Vector-Borne Pathogens in Ectoparasites Collected from High-Elevation Pika Populations.EcoHealth · 2020Article
- Human plague: An old scourge that needs new answers.PLoS neglected tropical diseases · 2020Review
- Prairie Dogs, Persistent Plague, Flocking Fleas, and Pernicious Positive Feedback.Frontiers in veterinary science · 2019Article
- Yersinia pestis Survival and Replication in Potential Ameba Reservoir.Emerging infectious diseases · 2018Article
- The One Health Concept: 10 Years Old and a Long Road Ahead.Frontiers in veterinary science · 2018Review
- Evolution with a seed bank: The population genetic consequences of microbial dormancy.Evolutionary applications · 2018Review
- Evaluation of Yersinia pestis Transmission Pathways for Sylvatic Plague in Prairie Dog Populations in the Western U.S.EcoHealth · 2016Review
- Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague.Infection and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plague, caused by the bacterium Yersinia pestis, is a mammalian vector-borne disease, transmitted by fleas that serve as the vector between rodent hosts. For many pathogens, including Y. pestis, there are strong evolutionary pressures that lead to a reduction in 'useless genes', with only those retained that reflect function in the specific environment inhabited by the pathogen. Genetic traits critical for survival and transmission between two environments, the rodent and the flea, are conserved in epizootic/epidemic plague strains. However, there are genes that remain conserved for which no function in the flea-rodent cycle has yet been observed, indicating an additional environment may exist in the transmission cycle of plague. Here, we present evidence for highly conserved genes that suggests a role in the persistence of Y. pestis after death of its host. Furthermore, maintenance of these genes points to Y. pestis traversing a post-mortem path between, and possibly within, epizootic periods and offering insight into mechanisms that may allow Y. pestis an alternative route of transmission in the natural environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.