Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Using an experimental medicine model to explore combination effects of pharmacological and cognitive interventions for depression and anxiety.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Early effects of duloxetine on emotion recognition in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2015Trial
- Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships.Social cognitive and affective neuroscience · 2014Trial
- Using attentional bias modification as a cognitive vaccine against depression.Biological psychiatry · 2012Trial
- Improving mental health outcomes through online brain health training in adults with or without mental illness.Frontiers in psychology · 2026Article
- A comparison of the effectiveness of cognitive behavioural interventions based on delivery features for elevated symptoms of depression in adolescents: A systematic review.Campbell systematic reviews · 2024Review
- The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake.Frontiers in neuroscience · 2022Article
- Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.Psychopharmacology · 2021Review
- From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018Article
- Referential focus moderates depression-linked attentional avoidance of positive information.Behaviour research and therapy · 2017Article
- How do antidepressants work? New perspectives for refining future treatment approaches.The lancet. Psychiatry · 2017Review
- The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment.Dialogues in clinical neuroscience · 2015Review
- MDMA for the treatment of mood disorder: all talk no substance?Therapeutic advances in psychopharmacology · 2015Review
- Positive Imagery-Based Cognitive Bias Modification as a Web-Based Treatment Tool for Depressed Adults: A Randomized Controlled Trial.Clinical psychological science : a journal of the Association for Psychological Science · 2015Article
- Cognitive training in mental disorders: update and future directions.The American journal of psychiatry · 2014Review
- Article
- Cognitive Bias Modification Using Mental Imagery for Depression: Developing a Novel Computerized Intervention to Change Negative Thinking Styles.European journal of personality · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Selective serotonergic reuptake inhibitors (SSRIs) and cognitive therapies are effective in the treatment of anxiety and depression. Previous research suggests that both forms of treatments may work by altering cognitive biases in the processing of affective information. The current study assessed the effects of combining an SSRI with a cognitive intervention on measures of affective processing bias and resilience to external challenge. A total of 62 healthy participants were randomly assigned to receive either 7 days of citalopram (20 mg) or placebo capsules while also completing either an active or a control version of a computerized cognitive bias training task. After treatment, standard measures of affective processing bias were collected. Participants' resilience to external stress was also tested by measuring the increase in negative symptoms induced by a negative mood induction. Participants who received both citalopram and the active cognitive bias training task showed a smaller alteration in emotional memory and categorization bias than did those who received either active intervention singly. The degree to which memory for negative information was altered by citalopram predicted participants' resistance to the negative mood induction. These results suggest that co-administration of an SSRI and a cognitive training intervention can reduce the effectiveness of either treatment alone in terms of anxiety- and depression-relevant emotional processing. More generally, the findings suggest that pinpointing the cognitive actions of treatments may inform future development of combination strategies in mental health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.