ArticleMolecular & cellular proteomics : MCP2011
Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts.
Article in Molecular & cellular proteomics : MCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Human Retinal Progenitor Cell (hRPC) Migration in Three-Dimensional (3D) Environments of Varying Stiffness and Composition.Journal of tissue engineering and regenerative medicine · 2025Article
- Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis.Frontiers in cell and developmental biology · 2023Review
- Cell surface integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition.Cancer research · 2021Article
- Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition.Cell death & disease · 2020Article
- Using Statistical Modeling to Understand and Predict Pediatric Stem Cell Function.Circulation. Genomic and precision medicine · 2019Article
- Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data.Essays in biochemistry · 2018Review
- Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.Experimental and therapeutic medicine · 2017Article
- The Many-Faced Program of Epithelial-Mesenchymal Transition: A System Biology-Based View.Frontiers in oncology · 2017Review
- An atlas of human kinase regulation.Molecular systems biology · 2016Article
- The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity.Cell systems · 2015Article
- Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks.Cellular signalling · 2015Article
- Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.Molecular and cellular biology · 2014Article
- Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models.Frontiers in oncology · 2014Article
- Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.Molecular & cellular proteomics : MCP · 2013Article
- The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells.Science signaling · 2013Article
- Targeting tumor cell motility as a strategy against invasion and metastasis.Trends in pharmacological sciences · 2013Review
- Dynamic transcription factor networks in epithelial-mesenchymal transition in breast cancer models.PloS one · 2013Article
- 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.The Journal of cell biology · 2012Article
- Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer.Current opinion in cell biology · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Epithelial-mesenchymal transition (EMT), whether in developmental morphogenesis or malignant transformation, prominently involves modified cell motility behavior. Although major advances have transpired in understanding the molecular pathways regulating the process of EMT induction per se by certain environmental stimuli, an important outstanding question is how the activities of signaling pathways governing motility yield the diverse movement behaviors characteristic of pre-induction versus postinduction states across a broad landscape of growth factor contexts. For the particular case of EMT induction in human mammary cells by ectopic expression of the transcription factor Twist, we found the migration responses to a panel of growth factors (EGF, HRG, IGF, HGF) dramatically disparate between confluent pre-Twist epithelial cells and sparsely distributed post-Twist mesenchymal cells-but that a computational model quantitatively integrating multiple key signaling node activities could nonetheless account for this full range of behavior. Moreover, motility in both conditions was successfully predicted a priori for an additional growth factor (PDGF) treatment. Although this signaling network state model could comprehend motility behavior globally, modulation of the network interactions underlying the altered pathway activities was identified by ascertaining differences in quantitative topological influences among the nodes between the two conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.