ArticleNeurology2011
Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations.The Journal of neuropsychiatry and clinical neurosciences · 2014Pooled it
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- Bridging patterns of neurocognitive aging across the older adult lifespan.Neuroscience and biobehavioral reviews · 2022Review
- Neuroimaging in the Oldest-Old: A Review of the Literature.Journal of Alzheimer's disease : JAD · 2021Review
- [Not Available].Canadian geriatrics journal : CGJ · 2016Article
- The New Criteria for Alzheimer's Disease - Implications for Geriatricians.Canadian geriatrics journal : CGJ · 2016Article
- Brain imaging of neurovascular dysfunction in Alzheimer's disease.Acta neuropathologica · 2016Review
- Article
- Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Article
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old.Alzheimer's research & therapy · 2015Article
- Atlas-based diffusion tensor imaging correlates of executive function.Journal of Alzheimer's disease : JAD · 2015Article
- Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies.NeuroImage. Clinical · 2015Article
- APOE Affects the Volume and Shape of the Amygdala and the Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease: Age Matters.Journal of Alzheimer's disease : JAD · 2015Article
- APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Interactive effects of vascular risk burden and advanced age on cerebral blood flow.Frontiers in aging neuroscience · 2014Article
- The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Rates of decline in Alzheimer disease decrease with age.PloS one · 2012Article
- Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2012Article
- Age, Alzheimer's disease, and the big picture.International psychogeriatrics · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether age-standardized brain morphometric and cognitive profiles differ in young-old (aged 60-75 years) and very-old (aged 80-91 years) patients with Alzheimer disease (AD).
methodsUsing a case-control retrospective design, we compared hippocampal volume and cortical gray matter thickness in areas known to be affected by AD in 105 patients with AD and 125 healthy control (HC) participants divided into young-old and very-old subgroups. Brain morphometric and cognitive scores of the AD groups were standardized to their respective age-appropriate HC subgroup and then compared.
resultsSeveral cognitive domains (executive function, immediate memory, and attention/processing speed) were less abnormal in the very old with AD than in the young old with AD. Similarly, the very old with AD showed less severe cortical thinning than the young old with AD in the left posterior cingulate cortex, right lateral temporal cortex, and bilateral parietal cortex and in overall cortical thickness. This effect is partially explained by an age-related decrease in cortical thickness in these brain regions in the HC participants.
conclusionsThe typical pattern of AD-related cognitive and morphometric changes seen in the young old appear to be less salient in the very old. Thus, mild cases of AD in the very old may go undetected if one expects to see the prototypical pattern and severity of cognitive or brain changes that occur in the young old with AD. These results underscore the importance of interpreting neuropsychological test performance and morphometric brain measures in reference to the individual's age.
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Registered trials
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