ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
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- Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation.Molecules (Basel, Switzerland) · 2025Article
- Epigenetic regulation of natural killer cell memory.Immunological reviews · 2022Review
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- Neurokinin-1 Receptor Signaling Is Required for Efficient CaCell reports · 2020Article
- Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Long-Range Transcriptional Control of the Il2 Gene by an Intergenic Enhancer.Molecular and cellular biology · 2015Article
- Article
- Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.PloS one · 2014Article
- NFATc2 recruits cJun homodimers to an NFAT site to synergistically activate interleukin-2 transcription.Molecular immunology · 2013Article
- Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation.In vitro cellular & developmental biology. Animal · 2013Article
- Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.The Journal of biological chemistry · 2012Article
- Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation.The Journal of biological chemistry · 2012Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
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Abstract
Most gene promoters have multiple binding sequences for many transcription factors, but the contribution of each of these factors to chromatin remodeling is still unclear. Although we previously found a dynamic change in the arrangement of nucleosome arrays at the Il2 promoter during T cell activation, its timing preceded that of a decrease in nucleosome occupancy at the promoter. In this article, we show that the initial nucleosome rearrangement was temporally correlated with the binding of NFAT1 and AP-1 (Fos/Jun), whereas the second step occurred in parallel with the recruitment of other transcription factors and RNA polymerase II. Pharmacologic inhibitors for activation of NFAT1 or induction of Fos blocked the initial phase in the sequential changes. This step was not affected, however, by inhibition of c-Jun phosphorylation, which instead blocked the binding of the late transcription factors, the recruitment of CREB-binding protein, and the acetylation of histone H3 at lysine 27. Thus, the sequential recruitment of transcription factors appears to facilitate two separate steps in chromatin remodeling at the Il2 locus.
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