ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.Seminars in immunopathology · 2016Review
- Article
- Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.Journal of autoimmunity · 2014Article
- Islet inflammation: a unifying target for diabetes treatment?Trends in endocrinology and metabolism: TEM · 2013Review
- Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.Clinical and experimental immunology · 2013Review
- The role of T helper (TH)17 cells as a double-edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic-induced immunomodulation.Clinical & developmental immunology · 2013Review
- Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells.Immunologic research · 2012Review
- Autoimmunity in 2011.Clinical reviews in allergy & immunology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have shown that IL-17 can contribute beneficially to pathogen defense but also that excessive IL-17 levels are associated with chronic inflammation and autoimmune disorders. To date, the role of IL-17 in viral infections and type 1 diabetes is ambiguous. In this study, we used IL-17A enhanced green fluorescent protein bicistronic reporter mouse strains to analyze in situ production of IL-17A. Upon Klebsiella pneumoniae bacterial infection, CD4(+) and γδ T cells produce IL-17A. In contrast, CD4(+) or CD8(+) T cells do not produce IL-17A in response to acute or protracted viral infection with lymphocytic choriomeningitis virus or during autoimmune diabetes development in the CD8-driven lymphocytic choriomeningitis virus-induced model of type 1 diabetes. We conclude that viral elimination and type 1 diabetes can occur in the absence of detectable IL-17A production, suggesting IL-17A is not essential in these settings.
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Registered trials
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