ArticleJournal of immunology (Baltimore, Md. : 1950)2011
The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Predicting Durable Anti-tumor Immune Responses after Cancer Vaccines.Journal of cancer immunology · 2026Article
- Magnitude of antigen-specific T-cell immunity the month after completing vaccination series predicts the development of long-term persistence of antitumor immune response.Journal for immunotherapy of cancer · 2024Article
- Memory CD8Immunology · 2021Article
- Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes.Frontiers in immunology · 2018Review
- Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.The Journal of clinical investigation · 2016Article
- Antigen-dependent and -independent contributions to primary memory CD8 T cell activation and protection following infection.Scientific reports · 2015Article
- The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.PLoS pathogens · 2015Article
- Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.PLoS pathogens · 2015Article
- Irradiated tumor cells of lipopolysaccharide stimulation elicit an enhanced anti-tumor immunity.Journal of cancer research and clinical oncology · 2014Article
- Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Memory CD8⁺ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection.Cell host & microbe · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
One goal of immunization is to generate memory CD8 T cells of sufficient quality and quantity to confer protection against infection. It has been shown that memory CD8 T cell differentiation in vivo is controlled, at least in part, by the amount and duration of infection, Ag, and inflammatory cytokines present early after the initiation of the response. In this study, we used models of anti-vectorial immunity to investigate the impact of pre-existing immunity on the development and differentiation of vector-induced primary CD8 T cell responses. We showed that existing CD8 T cell memory influences the magnitude of naive CD8 T cell responses. However, the differentiation of newly recruited (either TCR-transgenic or endogenous) primary CD8 T cells into populations with the phenotype (CD62L(hi), CD27(hi), KLRG-1(low)) and function (tissue distribution, Ag-driven proliferation, cytokine production) of long-term memory was facilitated when they were primed in the presence of vector-specific memory CD8 T cells of the same or unrelated specificity. Therefore, these data suggested that the presence of anti-vectorial immunity impacts the rate of differentiation of vector-induced naive CD8 T cells, a notion with important implications for the design of future vaccination strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.