ArticleMolecular biology of the cell2011
Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 88 citations in OpenAlex.
- Mitochondrial dysfunction alters early endosome trafficking via microtubule reorganization.Life science alliance · 2026Article
- Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes inMolecular biology of the cell · 2025Article
- Deciphering the RNA-binding protein network during endosomal mRNA transport.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Pseudokinase NRP1 facilitates endocytosis of transferrin in the African trypanosome.Scientific reports · 2022Article
- Kinesin Motors in the Filamentous Basidiomycetes in Light of theJournal of fungi (Basel, Switzerland) · 2022Review
- Linking transport and translation of mRNAs with endosomes and mitochondria.EMBO reports · 2021Review
- Intracellular mRNA transport and localized translation.Nature reviews. Molecular cell biology · 2021Review
- Membrane Traffic inJournal of fungi (Basel, Switzerland) · 2021Review
- Modelling the motion of organelles in an elongated cell via the coordination of heterogeneous drift-diffusion and long-range transport.The European physical journal. E, Soft matter · 2021Article
- Axonal transport and neurological disease.Nature reviews. Neurology · 2019Review
- The multi PAM2 protein Upa2 functions as novel core component of endosomal mRNA transport.EMBO reports · 2019Article
- ESCRT Mutant Analysis and Imaging of ESCRT Components in the Model Fungus Ustilago maydis.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures.Microbiology and molecular biology reviews : MMBR · 2018Review
- Cytoplasmic Transport Machinery of the SPF27 Homologue Num1 in Ustilago maydis.Scientific reports · 2018Article
- Superresolution and pulse-chase imaging reveal the role of vesicle transport in polar growth of fungal cells.Science advances · 2018Article
- Spatial organization of organelles in fungi: Insights from mathematical modelling.Fungal genetics and biology : FG & B · 2017Review
- The ESCRT regulator Did2 maintains the balance between long-distance endosomal transport and endocytic trafficking.PLoS genetics · 2017Article
- Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells.Nature communications · 2016Article
- Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics.Marine drugs · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The polarity of microtubules (MTs) determines the motors for intracellular motility, with kinesins moving to plus ends and dynein to minus ends. In elongated cells of Ustilago maydis, dynein is thought to move early endosomes (EEs) toward the septum (retrograde), whereas kinesin-3 transports them to the growing cell tip (anterograde). Occasionally, EEs run up to 90 μm in one direction. The underlying MT array consists of unipolar MTs at both cell ends and antipolar bundles in the middle region of the cell. Cytoplasmic MT-organizing centers, labeled with a γ-tubulin ring complex protein, are distributed along the antipolar MTs but are absent from the unipolar regions. Dynein colocalizes with EEs for 10-20 μm after they have left the cell tip. Inactivation of temperature-sensitive dynein abolishes EE motility within the unipolar MT array, whereas long-range motility is not impaired. In contrast, kinesin-3 is continuously present, and its inactivation stops long-range EE motility. This indicates that both motors participate in EE motility, with dynein transporting the organelles through the unipolar MT array near the cell ends, and kinesin-3 taking over at the beginning of the medial antipolar MT array. The cooperation of both motors mediates EE movements over the length of the entire cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.