ArticleThe Journal of biological chemistry2011
Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- The front line of defence: a meta-analysis of apoplastic proteases in plant immunity.Journal of experimental botany · 2021Pooled it
- Incorporation of Multiple βACS central science · 2024Article
- A Novel Trypsin Kunitz-Type Inhibitor from Cajanus cajan Leaves and Its Inhibitory Activity on New Cancer Serine Proteases and Its Effect on Tumor Cell Growth.The protein journal · 2024Article
- Review
- Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease.International journal of molecular sciences · 2023Review
- Recent advances in the production, properties and applications of haloextremozymes protease and lipase from haloarchaea.World journal of microbiology & biotechnology · 2023Review
- Approaches to Avoid Proteolysis During Protein Expression and Purification.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Fungal alkaline proteases and their potential applications in different industries.Frontiers in microbiology · 2023Review
- Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host's body temperature.Scientific reports · 2022Article
- Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications.Plants (Basel, Switzerland) · 2022Review
- Insights into the proteomic profile of newly harvested corn and metagenomic analysis of the broiler intestinal microbiota.Journal of animal science and biotechnology · 2022Article
- Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters.ACS omega · 2022Article
- Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms.Journal of experimental botany · 2021Article
- How to use the MEROPS database and website to help understand peptidase specificity.Protein science : a publication of the Protein Society · 2021Article
- Genomic insights into the lifestyles, functional capacities and oleagenicity of members of the fungal family Trichosporonaceae.Scientific reports · 2020Article
- Disruption of a C69-Family Cysteine Dipeptidase Gene Enhances Heat Shock and UV-B Tolerances inFrontiers in microbiology · 2020Article
- Origins of peptidases.Biochimie · 2019Article
- Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group-A Model for yet Unknown Peptidases?Molecules (Basel, Switzerland) · 2019Article
- The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.Nucleic acids research · 2018Article
- Specificity of peptidases secreted by filamentous fungi.Bioengineered · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The terms "proteolytic enzyme" and "peptidase" have been treated as synonymous, and all proteolytic enzymes have been considered to be hydrolases (EC 3.4). However, the recent discovery of proteins that cleave themselves at asparagine residues indicates that not all peptide bond cleavage occurs by hydrolysis. These self-cleaving proteins include the Tsh protein precursor of Escherichia coli, in which the large C-terminal propeptide acts as an autotransporter; certain viral coat proteins; and proteins containing inteins. Proteolysis is the action of an amidine lyase (EC 4.3.2). These proteolytic enzymes are also the first in which the nucleophile is an asparagine, defining the seventh proteolytic catalytic type and the first to be discovered since 2004. We have assembled ten families based on sequence similarity in which cleavage is thought to be catalyzed by an asparagine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.