ArticleThe Journal of biological chemistry2011
Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- REST Is Not Resting: REST/NRSF in Health and Disease.Biomolecules · 2023Review
- Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies.Molecular neurobiology · 2023Review
- Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease.Journal of Huntington's disease · 2022Article
- Silencing HIPPI Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Inhibiting DNA Replication.OncoTargets and therapy · 2021Article
- Article
- REST overexpression in mice causes deficits in spontaneous locomotion.Scientific reports · 2018Article
- Differential alterations of positive and negative regulators of beta catenin enhance endogenous expression and activity of beta catenin in A549 non small cell lung cancer (NSCLC) cells.Genes & diseases · 2016Article
- FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter.Oncology reports · 2016Article
- Transcription regulation of HYPK by Heat Shock Factor 1.PloS one · 2014Article
- Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.PloS one · 2013Article
- Mechanism(s) of alteration of micro RNA expressions in Huntington's disease and their possible contributions to the observed cellular and molecular dysfunctions in the disease.Neuromolecular medicine · 2012Review
- Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation.BMC genomics · 2011Article
- Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Earlier we have shown that the proapoptotic protein HIPPI (huntingtin interacting protein 1 (HIP1) protein interactor) along with its molecular partner HIP1 could regulate transcription of the caspase-1 gene. Here we report that RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a new transcriptional target of HIPPI. HIPPI could bind to the promoter of REST and increased its expression in neuronal as well as non-neuronal cells. Such activation of REST down-regulated expression of REST target genes, such as brain-derived neurotrophic factor (BDNF) or proenkephalin (PENK). The ability of HIPPI to activate REST gene transcription was dependent on HIP1, the nuclear transporter of HIPPI. Using a Huntington disease cell model, we have demonstrated that feeble interaction of HIP1 with mutant huntingtin protein resulted in increased nuclear accumulation of HIPPI and HIP1, leading to higher occupancy of HIPPI at the REST promoter, triggering its transcriptional activation and consequent repression of REST target genes. This novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease.
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