ArticleJournal of clinical microbiology2011
Extent of antigenic cross-reactivity among highly pathogenic H5N1 influenza viruses.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Effect of a straw-derived xylooligosaccharide on broiler growth performance, endocrine metabolism, and immune response.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Trial
- Predictable Irreversible Switching Between Acute and Chronic Inflammation.Frontiers in immunology · 2018Article
- Cocktail of H5N1 COBRA HA vaccines elicit protective antibodies against H5N1 viruses from multiple clades.Human vaccines & immunotherapeutics · 2015Article
- Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Turkey versus guinea pig red blood cells: hemagglutination differences alter hemagglutination inhibition responses against influenza A/H1N1.Viral immunology · 2014Article
- Antigenic and genetic evolution of low-pathogenicity avian influenza viruses of subtype H7N3 following heterologous vaccination.Clinical and vaccine immunology : CVI · 2014Article
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- Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs.Journal of virology · 2013Article
- Antigenic characterization of recent H5N1 highly pathogenic avian influenza viruses circulating in Egyptian poultry.Virology · 2013Article
- Identifying antigenicity-associated sites in highly pathogenic H5N1 influenza virus hemagglutinin by using sparse learning.Journal of molecular biology · 2012Article
- AntigenMap 3D: an online antigenic cartography resource.Bioinformatics (Oxford, England) · 2012Article
- Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Highly pathogenic H5N1 avian influenza viruses emerged in 1996 and have since evolved so extensively that a single strain can no longer be used as a prepandemic vaccine or diagnostic reagent. We therefore sought to identify the H5N1 strains that may best serve as cross-reactive diagnostic reagents. We compared the cross-reactivity of 27 viruses of clades 0, 1, 2.1, 2.2, 2.3, and 4 and of four computationally designed ancestral H5N1 strains by hemagglutination inhibition (HI) and microneutralization (MN) assays. Antigenic cartography was used to analyze the large quantity of resulting data. Cartographs of HI titers with chicken red blood cells were similar to those of MN titers, but HI with horse red blood cells decreased antigenic distances among the H5N1 strains studied. Thus, HI with horse red blood cells seems to be the assay of choice for H5N1 diagnostics. Whereas clade 2.2 antigens were able to detect antibodies raised to most of the tested H5N1 viruses (and clade 2.2-specific antisera detected most of the H5N1 antigens), ancestral strain A exhibited the widest reactivity pattern and hence was the best candidate diagnostic reagent for broad detection of H5N1 strains.
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