ArticleNucleic acids research1990
Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.Nucleic acids research · 2018Article
- Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes.PLoS genetics · 2017Article
- Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-β signaling.The Journal of biological chemistry · 2014Article
- Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.Journal of cellular biochemistry · 2012Article
- Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.The Journal of biological chemistry · 2011Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity.Nucleic acids research · 2002Article
- Article
- Ski interacts with the evolutionarily conserved SNW domain of Skip.Nucleic acids research · 2001Article
- The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.Genes & development · 1999Article
- Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.Genes & development · 1999Article
- Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation: the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes.The Biochemical journal · 1997Article
- DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI.Nucleic acids research · 1997Article
- Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.Genes & development · 1997Article
- Activation of a muscle-specific enhancer by the Ski proto-oncogene.Nucleic acids research · 1995Article
- Binding of a 50-kD Protein to a U-Rich Sequence in an mRNA Encoding a Proline-Rich Protein That Is Destabilized by Fungal Elicitor.The Plant cell · 1994Article
- Fungal Elicitor-Induced Bean Proline-Rich Protein mRNA Down-Regulation Is Due to Destabilization That Is Transcription and Translation Dependent.The Plant cell · 1993Article
- C-ski cDNAs are encoded by eight exons, six of which are closely linked within the chicken genome.Nucleic acids research · 1992Article
- Activation of the c-ski oncogene by overexpression.Journal of virology · 1991Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified the human c-ski gene product (c-Ski) as a protein with the apparent molecular weight of 100,000, p100c-ski, by using a c-Ski-specific polyclonal antibody. p100c-ski was a nuclear protein and p100c-ski in nuclear extracts of Molt4 cells bound to calf thymus DNA cellulose, but the bacterially synthesized c-Ski did not, suggesting that Ski was associated with another protein(s) and that the Ski complex had DNA-binding activity. This hypothesis was supported by the finding that the bacterially synthesized Ski bounds to DNA cellulose after being mixed with a nuclear extract of Molt4 cells. By use of a series of deletion mutants of Ski synthesized in an in vitro translation system, two portions in Ski were found to be necessary for the DNA binding of the Ski complex: the N-proximal portion containing a cystein/histidine-rich domain and the C-terminal portion including a region rich in basic amino acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.