ArticleSchizophrenia research2011
Fiber geometry in the corpus callosum in schizophrenia: evidence for transcallosal misconnection.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis.Neurology · 2020Article
- Lifespan Trajectories of White Matter Changes in Rhesus Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia.Schizophrenia bulletin · 2019Article
- Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2017Article
- Sexual dimorphic abnormalities in white matter geometry common to schizophrenia and non-psychotic high-risk subjects: Evidence for a neurodevelopmental risk marker?Human brain mapping · 2016Article
- Polymorphism within a Neuronal Activity-Dependent Enhancer of NgR1 Is Associated with Corpus Callosum Morphology in Humans.Molecular neuropsychiatry · 2015Article
- Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Distribution of tract deficits in schizophrenia.BMC psychiatry · 2014Article
- Increased stability of microtubules in cultured olfactory neuroepithelial cells from individuals with schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2014Article
- Localized abnormalities in the cingulum bundle in patients with schizophrenia: a Diffusion Tensor tractography study.NeuroImage. Clinical · 2014Article
- Attenuation of corpus callosum axon myelination and remyelination in the absence of circulating sex hormones.Brain pathology (Zurich, Switzerland) · 2013Article
- Validating serum S100B and neuron-specific enolase as biomarkers for the human brain - a combined serum, gene expression and MRI study.PloS one · 2012Article
- MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundStructural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia.
aimsTo investigate for geometric abnormalities in these callosal fibers in schizophrenia patients by using a novel Diffusion-Tensor Imaging (DTI) metric of fiber geometry named Shape-Normalized Dispersion (SHD).
methodsDTIs (3T, 51 gradient directions, 1.7mm isotropic voxels) were acquired from 26 schizophrenia patients and 23 matched healthy controls. The prefrontal and temporoparietal fibers of the corpus callosum were extracted by means of whole-brain tractography, and their mean SHD calculated.
resultsThe schizophrenia patients exhibited subnormal levels of SHD in the prefrontal callosal fibers when controlling for between-group differences in Fractional Anisotropy. Reduced SHD could reflect either irregularly turbulent or inhomogeneously distributed fiber trajectories in the corpus callosum.
conclusionsThe results suggest that the transcallosal misconnectivity thought to be associated with schizophrenia could reflect abnormalities in fiber geometry. These abnormalities in fiber geometry could potentially be underpinned by neurodevelopmental irregularities.
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