ArticleMolecular immunology2011
NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus.
Article in Molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
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- Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia.Scientific reports · 2023Article
- CD4Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.Mucosal immunology · 2021Article
- Immuno-suppressive function of nucleus-transducible BAF57-ΔPH in T cell activation via degradation of endogenous BAF57.International journal of hematology · 2018Article
- Sca-1European journal of immunology · 2018Article
- Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.Frontiers in immunology · 2018Article
- Article
- Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.Nature communications · 2014Article
- Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels.PloS one · 2013Article
- The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme.BMC immunology · 2012Article
- ATP-dependent chromatin remodeling in T cells.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2012Review
- CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.PloS one · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated gene regulation at the IL-3/GM-CSF gene cluster. We found BRG1, a SWI/SNF remodeling ATPase, bound a distal element, CNSa. BRG1 binding was strongest in differentiated, stimulated T helper cells, paralleling IL-3 and GM-CSF expression. Depletion of BRG1 reduced IL-3 and GM-CSF transcription. BAF-specific SWI/SNF subunits bound to this locus and regulated IL-3 expression. CNSa was in closed chromatin in fibroblasts, open chromatin in differentiated T helper cells, and moderately open chromatin in naïve (undifferentiated) T helper cells; BRG1 was required for the most open state. CNSa increased transcription of a reporter in an episomal expression system, in a BRG1-dependent manner. The NF-κB subunit RelA/p65 bound CNSa in activated T helper cells. Inhibition of NF-κB blocked BRG1 binding to CNSa, chromatin opening at CNSa, and activation of IL-3 and GM-CSF. Together, these findings suggest CNSa is a distal enhancer that binds BRG1 and NF-κB.
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