ArticleBrain research2011
Distribution of voltage gated calcium channel β subunits in the mouse retina.
Article in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels.Channels (Austin, Tex.) · 2023Article
- Electrical activation of degenerated photoreceptors in blind mouse retina elicited network-mediated responses in different types of ganglion cells.Scientific reports · 2018Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- αThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Characterization of C-terminal Splice Variants of Cav1.4 Ca2+ Channels in Human Retina.The Journal of biological chemistry · 2016Article
- Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina.Investigative ophthalmology & visual science · 2016Article
- Characterization of Cav1.4 complexes (α11.4, β2, and α2δ4) in HEK293T cells and in the retina.The Journal of biological chemistry · 2015Article
- Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Frontiers in molecular neuroscience · 2014Review
- EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.Frontiers in molecular neuroscience · 2012Article
- Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Voltage gated calcium channels (VGCCs) are essential to neuronal excitation and signal transduction. They are multimeric in structure and comprised of an alpha subunit that functions as a calcium pore and two additional subunits: an alpha2delta subunit and a cytoplasmic beta subunit. To better understand the role of VGCCs in the retina we used immunohistochemical methods to determine the distribution of VGCC β subunits in normal and mutant mice. To verify the specificity of each antibody and to examine the potential for subunit redistribution when beta subunit expression is perturbed, we used 4 mutant mouse lines that each lack a specific β subunit isoform (β(1)-β(4)). We found the β(1) subunit distributed on cell bodies in the inner nuclear layer (INL) and on processes within both the inner and outer limiting membrane; the β(2) subunit localized to the outer plexiform layer (OPL) and inner plexiform layer (IPL); the β(3) subunit was localized to three narrow and distinct bands within the IPL; the β(4) subunit was localized to three diffuse bands within the IPL. Loss of one β subunit affected labeling intensity but not general distribution patterns of other β subunits. It is likely that VGCCs critical for retinal signal transmission are comprised of the β(2) subunit in the OPL and any of the 4 β subunits in the IPL. Our results suggest that within the OPL the α(1F) subunit pairs predominantly with the β(2) subunit while within the IPL it may pair with either any β subunit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.