ArticleAmerican journal of obstetrics and gynecology2011
Alterations in maternal and fetal heart functions accompany failed spiral arterial remodeling in pregnant mice.
Article in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cardiac lymphatics undergo distinct remodeling during hypertrophic and nonhypertrophic pregnancy.American journal of physiology. Heart and circulatory physiology · 2024Article
- Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors.Frontiers in cell and developmental biology · 2024Review
- Human Chorionic Villous Differentiation and Placental Development.International journal of molecular sciences · 2022Review
- IFNs Drive Development of Novel IL-15-Responsive Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- The role of RORγt at maternal-fetal interface during murine pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Cross talk between natural killer cells and mast cells in tumor angiogenesis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Inactivation of maternal Hif-1α at mid-pregnancy causes placental defects and deficits in oxygen delivery to the fetal organs under hypoxic stress.Developmental biology · 2017Article
- Article
- Hypoxia stimulates the proliferation of neonatal rat vascular smooth muscle cells through activation of hypoxia-inducible factor-1α.International journal of clinical and experimental medicine · 2015Article
- Ly49 receptors activate angiogenic mouse DBA⁺ uterine natural killer cells.Cellular & molecular immunology · 2014Article
- Liaison between natural killer cells and dendritic cells in human gestation.Cellular & molecular immunology · 2014Review
- Evaluation of utero-placental and fetal hemodynamic parameters throughout gestation in pregnant mice using high-frequency ultrasound.Ultrasound in medicine & biology · 2014Article
- Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.Frontiers in immunology · 2014Review
- Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice.Placenta · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveOur goal was to define mechanisms that protect murine pregnancies deficient in spiral arterial remodeling from hypertension, hypoxia, and intrauterine growth restriction. STUDY
designMicroultrasound analyses were conducted on virgin, gestation day 2, 4, 7, 9, 10, 12, 14, 16, 18, and postpartum BALB/c (wild type) mice and BALB/c-Rag2(-/-)/Il2rg(-/-) mice, an immunodeficient strain lacking spiral arterial remodeling.
resultsRag2(-/-)/Il2rg(-/-) dams had normal spiral arterial flow velocities, greatly elevated uterine artery flow velocities between gestational day 10-16 and smaller areas of placental flow from gestational day 14 to term than controls. Maternal heart weight and output increased transiently. Conceptus alterations included higher flow velocities in the umbilical-placental circulation that became normal before term and bradycardia persistent to term.
conclusionTransient changes in maternal heart weight and function accompanied by fetal circulatory changes successfully compensate for deficient spiral arterial modification in mice. Similar compensations may contribute to the elevated risk for cardiovascular diseases seen in women and their children who experience preeclamptic pregnancies.
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