ArticleJournal of neuroinflammation2011
CRP gene variation affects early development of Alzheimer's disease-related plaques.
Article in Journal of neuroinflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis.Brain, behavior, & immunity - health · 2026Article
- Vascular Lesions, APOE ε4, and Tau Pathology in Alzheimer Disease.Journal of neuropathology and experimental neurology · 2021Article
- Editorial: Vascular Factors and Vascular Lesions in Pre-clinical Alzheimer's Disease.Frontiers in neurology · 2021Article
- Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease.Current neuropharmacology · 2020Review
- Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review.Current genomics · 2018Review
- Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.PLoS medicine · 2016Article
- The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis.Genes and immunity · 2015Article
- Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer's disease: a pilot study.Frontiers in cellular neuroscience · 2015Article
- KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer's Disease Patients.International journal of Alzheimer's disease · 2013Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's disease-related lesions.
methodsWe studied senile plaque (SP), neurofibrillary tangles (NFT) and SP phenotype associations with 6 reported haplotype tagging single nucleotide polymorphisms (SNPs) in the CRP gene. CRP and Aβ immunohistochemistry was assessed using brain tissue microarrays.
resultsIn multivariate analyses (age- and APOE-adjusted), non-neuritic SP were associated with the high-CRP TA-genotype (3.0% prevalence) of rs3091244 and CA-genotype (10.8%) of rs3093075 compared to common genotypes. Conversely, the low-CRP C allele (39.3%) of rs2794521 reduced the risk of harbouring early non-neuritic SP, compared to the TT genotype. CRP haplotype TAGCC (high) associated with non-neuritic SP, whereas haplotype CCGCC offered protection. TT genotypes (high) of rs3091244 and rs1130864 were associated with CRP staining. There were no associations between SNPs or haplotypes and NFT. CRP staining of the hippocampal CA1/2 region correlated with Aβ staining.
conclusionsCRP gene variation affects early SP development in prodromal Alzheimer's disease, independent of APOE genotype.
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