ArticleBMC genomics2011
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 3 of them syntheses that pooled it.
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Who cites it
219 citing papers in PubMed, 3 syntheses or guidelines pooled it, 520 citations in OpenAlex.
- Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.Genetics, selection, evolution : GSE · 2024Pooled it
- A meta-analysis of genetic and phenotypic diversity of European local pig breeds reveals genomic regions associated with breed differentiation for production traits.Genetics, selection, evolution : GSE · 2023Pooled it
- Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins.Scientific reports · 2017Pooled it
- SNP-based selection strategies reveal antagonistic and favorable genetic architectures between milk production and fertility traits in dairy cattle: A simulation study.Veterinary and animal science · 2026Article
- Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- Multi-trait GWAS of reaction norm parameters reveals environment-responsive loci influencing reproductive performance in heifers.Journal of animal science and biotechnology · 2026Article
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- Selection signatures on the autosomes and the X chromosome in the prolific Belclare sheep breed.Veterinary and animal science · 2026Article
- Genome-wide characterization of genetic diversity and breed discrimination markers in Tharparkar cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Runs of homozygosity reveal population dynamics and selection across global cattle.Journal of animal science and biotechnology · 2026Article
- Single- and Multi-Trait GWASs Combined with Genetic Parameter Estimation Reveal Candidate Genes for Body Conformation Traits in Sika Deer (Animals : an open access journal from MDPI · 2026Article
- Genome-wide association study identifies significant SNPs for milk production and stature traits in Karan Fries cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Detection of selection signatures in indigenous African cattle reveals genomic footprints of adaptation, production and temperament traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Identifying the Genetic Basis of Fetal Loss in Cows and Heifers Through a Genome-Wide Association Analysis.Animals : an open access journal from MDPI · 2026Article
- Identification of candidate genes for reproductive traits in Chinese Holstein cattle using single-step genome-wide association study.Journal of animal science · 2026Article
- Linking laboratory findings to field fertility: a comparative study of frozen semen from dairy and beef bulls.Frontiers in veterinary science · 2026Article
- Haplotypes affecting stillbirth and fertility in Icelandic Dairy Cattle.Journal of applied genetics · 2025Article
- Using single-step genome-wide association analyses to compare predicted negative energy balance and a novel energy deficiency score in early-lactation Holstein cows.JDS communications · 2025Article
- Article
159 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome-wide association analysis is a powerful tool for annotating phenotypic effects on the genome and knowledge of genes and chromosomal regions associated with dairy phenotypes is useful for genome and gene-based selection. Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows.
resultsGenome-wide association analysis identified a number of candidate genes and chromosome regions associated with 31 dairy traits in contemporary U.S. Holstein cows. Highly significant genes and chromosome regions include: BTA13's GNAS region for milk, fat and protein yields; BTA7's INSR region and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate, somatic cell score and productive life; BTA2's LRP1B for somatic cell score; BTA14's DGAT1-NIBP region for fat percentage; BTA1's FKBP2 for protein yields and percentage, BTA26's MGMT and BTA6's PDGFRA for protein percentage; BTA18's 53.9-58.7 Mb region for service-sire and daughter calving ease and service-sire stillbirth; BTA18's PGLYRP1-IGFL1 region for a large number of traits; BTA18's LOC787057 for service-sire stillbirth and daughter calving ease; BTA15's CD82, BTA23's DST and the MOCS1-LRFN2 region for daughter stillbirth; and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate. For body conformation traits, BTA11, BTAX, BTA10, BTA5, and BTA26 had the largest concentrations of SNP effects, and PHKA2 of BTAX and REN of BTA16 had the most significant effects for body size traits. For body shape traits, BTAX, BTA19 and BTA3 were most significant. Udder traits were affected by BTA16, BTA22, BTAX, BTA2, BTA10, BTA11, BTA20, BTA22 and BTA25, teat traits were affected by BTA6, BTA7, BTA9, BTA16, BTA11, BTA26 and BTA17, and feet/legs traits were affected by BTA11, BTA13, BTA18, BTA20, and BTA26.
conclusionsGenome-wide association analysis identified a number of genes and chromosome regions associated with 31 production, health, reproduction and body conformation traits in contemporary Holstein cows. The results provide useful information for annotating phenotypic effects on the dairy genome and for building consensus of dairy QTL effects.
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