ArticleMolecular and cellular biology1990
MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 124 citations in OpenAlex.
- The SR-protein Npl3 is an essential component of the meiotic splicing regulatory network in Saccharomyces cerevisiae.Nucleic acids research · 2021Article
- Mutagenesis of Snu114 domain IV identifies a developmental role in meiotic splicing.RNA biology · 2019Article
- The chromatin remodeling complex Swi/Snf regulates splicing of meiotic transcripts in Saccharomyces cerevisiae.Nucleic acids research · 2017Article
- Physiological Roles of DNA Double-Strand Breaks.Journal of nucleic acids · 2017Review
- Sporulation in the budding yeast Saccharomyces cerevisiae.Genetics · 2011Review
- Functional consequences of developmentally regulated alternative splicing.Nature reviews. Genetics · 2011Review
- Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue.RNA (New York, N.Y.) · 2011Article
- An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs.Nucleic acids research · 2011Article
- Determinants of Nam8-dependent splicing of meiotic pre-mRNAs.Nucleic acids research · 2011Article
- Integration of a splicing regulatory network within the meiotic gene expression program of Saccharomyces cerevisiae.Genes & development · 2010Article
- Ume6 is required for the MATa/MATalpha cellular identity and transcriptional silencing in Kluyveromyces lactis.Genetics · 2010Article
- Snu56p is required for Mer1p-activated meiotic splicing.Molecular and cellular biology · 2008Article
- Meiotic condensin is required for proper chromosome compaction, SC assembly, and resolution of recombination-dependent chromosome linkages.The Journal of cell biology · 2003Article
- The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast.The EMBO journal · 2002Article
- Impact of the six nucleotides downstream of the stop codon on translation termination.EMBO reports · 2001Article
- The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution.Genetics · 2001Article
- The origin of alternation of generations in land plants: a focus on matrotrophy and hexose transport.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site.Molecular and cellular biology · 1999Article
- Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.RNA (New York, N.Y.) · 1999Article
- Telomere-mediated chromosome pairing during meiosis in budding yeast.Genes & development · 1998Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The yeast MER1 gene is required for the production of viable meiotic products and for meiotic recombination. Cytological analysis of chromosome spreads from a mer1 mutant indicates that the MER1 gene product is also required for normal chromosome pairing. mer1 strains make axial elements, precursors to the synaptonemal complex; however, the chromosomes in most nuclei do not become fully synapsed. The DNA sequence of the MER1 coding region was determined; the MER1 open reading frame encodes a 270-amino-acid protein with a molecular mass of 31.1 kilodaltons. The MER1 protein shows limited sequence similarity to calmodulin. Expression of the MER1 gene was examined by RNA blot hybridization analysis and through the construction and analysis of mer1::lacZ fusion genes. Expression of the MER1 gene is meiotically induced and required the IME1 gene product. Thus, expression of the MER1 gene early in meiosis is required for proper chromosome pairing and meiotic recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.