ArticleMolecular and cellular biology1990
Differential regulation of the N-myc gene in transfected cells and transgenic mice.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- MYCN: from oncoprotein to tumor-associated antigen.Frontiers in oncology · 2012Article
- YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells.ASN neuro · 2011Article
- Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.Molecular and cellular biology · 2010Article
- Chromosomal location targets different MYC family gene members for oncogenic translocations.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- MYCN as a target for cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2008Article
- T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.Development (Cambridge, England) · 2005Article
- An alternative promoter of the human neuronal nitric oxide synthase gene is expressed specifically in Leydig cells.The American journal of pathology · 2002Article
- RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.The EMBO journal · 1996Article
- Both coding exons of the c-myc gene contribute to its posttranscriptional regulation in the quiescent liver and regenerating liver and after protein synthesis inhibition.Molecular and cellular biology · 1995Article
- cis regulation of the keratin 18 gene in transgenic mice.Molecular and cellular biology · 1993Article
- Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter.Molecular and cellular biology · 1992Article
- Transcriptional down-regulation of N-myc expression during B-cell development.Molecular and cellular biology · 1992Article
- Discordance between gene regulation in vitro and in vivo.Gene expression · 1992Review
- Regulation of N-myc gene expression: use of an adenovirus vector to demonstrate posttranscriptional control.Molecular and cellular biology · 1990Article
- A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice.The Journal of cell biology · 1990Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The N-myc gene is expressed specifically in the early developmental stages of numerous cell lineages. To assay for sequences that could potentially regulate N-myc expression, we transfected constructs that contained murine N-myc genomic sequences linked to a reporter gene and genomic clones that contained the complete human or murine N-myc genes into cell lines that either express or do not express the endogenous N-myc gene. Following either transient or stable transfection, the introduced N-myc sequences were expressed regardless of the expression status of the endogenous gene. In contrast, when the clones containing the complete human N-myc gene were introduced into the germline of transgenic mice, expression in some transgenic lines paralleled the tissue- and stage-specific expression of the endogenous murine gene. These findings demonstrate differences in the regulation of N-myc genes in recipient cells following in vitro versus in vivo introduction, suggesting that early developmental events may play a role in the regulation of N-myc expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.