ArticleEuropean journal of applied physiology2012
Resistance training restores the gene expression of molecules related to fat oxidation and lipogenesis in the liver of ovariectomized rats.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Muscle hypertrophy and ladder-based resistance training for rodents: A systematic review and meta-analysis.Physiological reports · 2020Pooled it
- Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis.International journal of molecular sciences · 2024Article
- Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet.American journal of physiology. Endocrinology and metabolism · 2023Article
- Effects of Melatonin Supplementation on Lipid Metabolism and Body Fat Accumulation in Ovariectomized Rats.Nutrients · 2023Article
- The Role of Fatty Acids in Non-Alcoholic Fatty Liver Disease Progression: An Update.International journal of molecular sciences · 2021Review
- Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate.Lipids in health and disease · 2020Article
- Benefits of resistance training on body composition and glucose clearance are inhibited by long-term low carbohydrate diet in rats.PloS one · 2018Article
- Physical training improves visceral adipose tissue health by remodelling extracellular matrix in rats with estrogen absence: a gene expression analysis.International journal of experimental pathology · 2017Article
- NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk.Advances in therapy · 2017Review
- A Herbal Formula HT051, a Combination ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue?Clinics (Sao Paulo, Brazil) · 2016Article
- GLUT2 proteins and PPARγ transcripts levels are increased in liver of ovariectomized rats: reversal effects of resistance training.Journal of exercise nutrition & biochemistry · 2016Article
- Effects of physical activity upon the liver.European journal of applied physiology · 2015Review
- Impact of various exercise modalities on hepatic mitochondrial function.Medicine and science in sports and exercise · 2014Article
- Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver.Clinics (Sao Paulo, Brazil) · 2013Article
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreased levels of estrogen are associated with hepatic steatosis (HS), through changes in gene expression of molecules related to fat oxidation and lipogenesis. Both resistance training (RT) and endurance training (ET) prevent HS in ovariectomized (Ovx) rats. However, the molecular events associated with this process were only investigated for ET, but not for RT. Thus, the aim of this study was to investigate the effects of Ovx and RT on the gene expression of molecules related to fat oxidation and lipogenesis in the liver of rats. Sprague-Dawley adult female rats were grouped into four (n = 6 per group): sham-operated sedentary (Sham-Sed); Ovx sedentary (Ovx-Sed); sham-Rt and Ovx-Rt. A 10-week RT period, during which the animals climbed a 1.1-m vertical ladder with weights attached to their tails, was used. The sessions were performed three times a week, with 4-9 climbs and 8-12 dynamic movements per climb. Gene expression was analyzed by RT-PCR by the ∆∆Ct method. The estrogen deficiency associated with ovariectomy decreased the gene expression of molecules related to fat oxidation, carnitine palmitoyltransferase I (53%) and β-hydroxyacyl-CoA dehydrogenase (27%), and increased molecules related to lipogenesis, sterol regulatory element-binding protein-1c (106%), acetyl-CoA carboxylase (ACC) (72%) and stearoyl CoA desaturase-1 (109%). With the exception of ACC, the ovariectomy-induced changes in the expression of these molecules were restored by RT. The present results indicate that RT has important effects on the prevention of HS in Ovx animals, through changes in gene expression of molecules related to hepatic lipid metabolism.
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