ArticlePloS one2011
Gold nanoparticle-based surface-enhanced Raman scattering for noninvasive molecular probing of embryonic stem cell differentiation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Inorganic Nanoparticles-Based Systems in Biomedical Applications of Stem Cells: Opportunities and Challenges.International journal of nanomedicine · 2023Review
- Live Cell Poration by Au Nanostars to Probe Intracellular Molecular Composition with SERS.Nanomaterials (Basel, Switzerland) · 2021Article
- A Protein and Membrane Integrity Study of TiOThe Journal of membrane biology · 2021Article
- Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques.Israel journal of chemistry · 2019Article
- Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging.Scientific reports · 2019Article
- Optical assays based on colloidal inorganic nanoparticles.The Analyst · 2018Review
- MgJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- Raman spectroscopy and regenerative medicine: a review.NPJ Regenerative medicine · 2017Review
- Novel surface-enhanced Raman scattering-based assays for ultra-sensitive detection of human pluripotent stem cells.Biomaterials · 2016Article
- Photothermal effects of laser-activated surface plasmonic gold nanoparticles on the apoptosis and osteogenesis of osteoblast-like cells.International journal of nanomedicine · 2016Article
- Gold Nanoparticles for In Vitro Diagnostics.Chemical reviews · 2015Review
- Photothermal confocal multicolor microscopy of nanoparticles and nanodrugs in live cells.Drug metabolism reviews · 2015Review
- Rhodamine 6G conjugated to gold nanoparticles as labels for both SERS and fluorescence studies on live endothelial cells.Mikrochimica acta · 2015Article
- Gold nanoparticle-spermidine complex blocks the inward rectifier potassium channel.American journal of cardiovascular disease · 2014Article
- In situ SERS monitoring of photochemistry within a nanojunction reactor.Nano letters · 2013Article
- Raman spectroscopic imaging of the whole Ciona intestinalis embryo during development.PloS one · 2013Article
- Stem cell tracking with optically active nanoparticles.American journal of nuclear medicine and molecular imaging · 2013Article
- Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.International journal of nanomedicine · 2013Article
- DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery.Current opinion in chemical biology · 2012Review
- Spectroscopic properties of gold nanoparticles at the single-particle level in biological environments.Chemphyschem : a European journal of chemical physics and physical chemistry · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports the use of gold nanoparticle-based surface-enhanced Raman scattering (SERS) for probing the differentiation of mouse embryonic stem (mES) cells, including undifferentiated single cells, embryoid bodies (EBs), and terminally differentiated cardiomyocytes. Gold nanoparticles (GNPs) were successfully delivered into all 3 mES cell differentiation stages without affecting cell viability or proliferation. Transmission electron microscopy (TEM) confirmed the localization of GNPs inside the following cell organelles: mitochondria, secondary lysosome, and endoplasmic reticulum. Using bright- and dark-field imaging, the bright scattering of GNPs and nanoaggregates in all 3 ES cell differentiation stages could be visualized. EB (an early differentiation stage) and terminally differentiated cardiomyocytes both showed SERS peaks specific to metabolic activity in the mitochondria and to protein translation (amide I, amide II, and amide III peaks). These peaks have been rarely identified in undifferentiated single ES cells. Spatiotemporal changes observed in the SERS spectra from terminally differentiated cardiomyocyte tissues revealed local and dynamic molecular interactions as well as transformations during ES cell differentiation.
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