ArticlePloS one2011
Workflow and atlas system for brain-wide mapping of axonal connectivity in rat.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Spatially integrated cortico-subcortical tracing data for analyses of rodent brain topographical organization.Scientific data · 2024Article
- The efferent connections of the orbitofrontal, posterior parietal, and insular cortex of the rat brain.Scientific data · 2023Article
- Myelination of Callosal Axons Is Hampered by Early and Late Forelimb Amputation in Rats.Cerebral cortex communications · 2021Article
- Connection strength of the macaque connectome augments topological and functional network attributes.Network neuroscience (Cambridge, Mass.) · 2019Article
- Spatial registration of serial microscopic brain images to three-dimensional reference atlases with the QuickNII tool.PloS one · 2019Article
- Diverse Long-Range Axonal Projections of Excitatory Layer 2/3 Neurons in Mouse Barrel Cortex.Frontiers in neuroanatomy · 2018Article
- Navigating the Murine Brain: Toward Best Practices for Determining and Documenting Neuroanatomical Locations in Experimental Studies.Frontiers in neuroanatomy · 2018Article
- Brain-Wide Mapping of Axonal Connections: Workflow for Automated Detection and Spatial Analysis of Labeling in Microscopic Sections.Frontiers in neuroinformatics · 2016Article
- Article
- Cyberinfrastructure for the digital brain: spatial standards for integrating rodent brain atlases.Frontiers in neuroinformatics · 2014Article
- Brain-wide map of efferent projections from rat barrel cortex.Frontiers in neuroinformatics · 2014Article
- Probing tissue microstructure with restriction spectrum imaging: Histological and theoretical validation.Human brain mapping · 2013Article
- Optogenetic approaches for functional mouse brain mapping.Frontiers in neuroscience · 2013Article
- Mapping the connectome: multi-level analysis of brain connectivity.Frontiers in neuroinformatics · 2012Article
- CoCoMac 2.0 and the future of tract-tracing databases.Frontiers in neuroinformatics · 2012Article
- Combining collation and annotation efforts toward completion of the rat and mouse connectomes in BAMS.Frontiers in neuroinformatics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detailed knowledge about the anatomical organization of axonal connections is important for understanding normal functions of brain systems and disease-related dysfunctions. Such connectivity data are typically generated in neuroanatomical tract-tracing experiments in which specific axonal connections are visualized in histological sections. Since journal publications typically only accommodate restricted data descriptions and example images, literature search is a cumbersome way to retrieve overviews of brain connectivity. To explore more efficient ways of mapping, analyzing, and sharing detailed axonal connectivity data from the rodent brain, we have implemented a workflow for data production and developed an atlas system tailored for online presentation of axonal tracing data. The system is available online through the Rodent Brain WorkBench (www.rbwb.org; Whole Brain Connectivity Atlas) and holds experimental metadata and high-resolution images of histological sections from experiments in which axonal tracers were injected in the primary somatosensory cortex. We here present the workflow and the data system, and exemplify how the online image repository can be used to map different aspects of the brain-wide connectivity of the rat primary somatosensory cortex, including not only presence of connections but also morphology, densities, and spatial organization. The accuracy of the approach is validated by comparing results generated with our system with findings reported in previous publications. The present study is a contribution to a systematic mapping of rodent brain connections and represents a starting point for further large-scale mapping efforts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.