ArticlePloS one2011
Endothelium-derived Netrin-4 supports pancreatic epithelial cell adhesion and differentiation through integrins α2β1 and α3β1.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip.Advanced healthcare materials · 2026Article
- Unveiling the significance of Netrin-1 and Netrin-4 in metabolic syndrome.Scientific reports · 2026Article
- Netrin‑4 promotes VE‑cadherin expression in endothelial cells through the NF‑κB signaling pathway.Experimental and therapeutic medicine · 2024Article
- NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.Nature communications · 2023Article
- Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors.Cellular and molecular neurobiology · 2023Review
- Bioactive semaphorin 3A promotes sequential formation of sensory nerve and type H vessels duringFrontiers in bioengineering and biotechnology · 2023Article
- NTN4 as a prognostic marker and a hallmark for immune infiltration in breast cancer.Scientific reports · 2022Article
- Review
- Screening of integrins localized on the surface of human epidermal melanocytes.In vitro cellular & developmental biology. Animal · 2020Article
- Involvement of Netrins and Their Receptors in Neuronal Migration in the Cerebral Cortex.Frontiers in cell and developmental biology · 2020Review
- Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications.Journal of diabetes research · 2018Review
- The biomechanical properties of an epithelial tissue determine the location of its vasculature.Nature communications · 2016Article
- Article
- Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.Journal of the American Society of Nephrology : JASN · 2015Article
- Netrin-5 is highly expressed in neurogenic regions of the adult brain.Frontiers in cellular neuroscience · 2015Article
- Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer.Oncotarget · 2015Article
- Therapeutic effects of topical netrin-4 in a corneal acute inflammatory model.International journal of ophthalmology · 2015Article
- Gene markers of cellular aging in human multipotent stromal cells in culture.Stem cell research & therapy · 2014Article
- Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells.Vascular cell · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNetrins have been extensively studied in the developing central nervous system as pathfinding guidance cues, and more recently in non-neural tissues where they mediate cell adhesion, migration and differentiation. Netrin-4, a distant relative of Netrins 1-3, has been proposed to affect cell fate determination in developing epithelia, though receptors mediating these functions have yet to be identified. METHODOLOGY/PRINCIPAL
findingsUsing human embryonic pancreatic cells as a model of developing epithelium, here we report that Netrin-4 is abundantly expressed in vascular endothelial cells and pancreatic ductal cells, and supports epithelial cell adhesion through integrins α2β1 and α3β1. Interestingly, we find that Netrin-4 recognition by embryonic pancreatic cells through integrins α2β1 and α3β1 promotes insulin and glucagon gene expression. In addition, full genome microarray analysis revealed that fetal pancreatic cell adhesion to Netrin-4 causes a prominent down-regulation of cyclins and up-regulation of negative regulators of the cell cycle. Consistent with these results, a number of other genes whose activities have been linked to developmental decisions and/or cellular differentiation are up-regulated. CONCLUSIONS/SIGNIFICANCE: Given the recognized function of blood vessels in epithelial tissue morphogenesis, our results provide a mechanism by which endothelial-derived Netrin-4 may function as a pro-differentiation cue for adjacent developing pancreatic cell populations expressing adhesion receptors α2β1 and α3β1 integrins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.