ArticlePloS one2011
Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1).
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 52 citations in OpenAlex.
- Human microRNA miR-197-3p positively regulates HIV-1 virion infectivity through its target DDX52 by stabilizing Vif protein expression.The Journal of biological chemistry · 2025Article
- Serum microRNA Biomarker Expression in HIV and TB: A Concise Overview.Infectious disorders drug targets · 2025Review
- Gene Expression Profiling Reveals New Pathways and Genes Associated with Visna/Maedi Viral Disease.Animals : an open access journal from MDPI · 2021Article
- Integrated mRNA and microRNA Transcriptome Sequencing Characterizes Sequence Variants and mRNA-microRNA Regulatory Networks in Grass Carp Fibroblasts Infected with Virulent and Attenuated GCRV.Marine biotechnology (New York, N.Y.) · 2021Article
- Differential expression and correlation analysis of miRNA-mRNA profiles in swine testicular cells infected with porcine epidemic diarrhea virus.Scientific reports · 2021Article
- Article
- Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies.Frontiers in oncology · 2019Review
- Elevated Expression of miR-19b Enhances CD8Frontiers in immunology · 2018Article
- Potential Application of MicroRNA Profiling to the Diagnosis and Prognosis of HIV-1 Infection.Frontiers in microbiology · 2018Review
- HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response.AIDS (London, England) · 2016Article
- Ruptured abdominal aortic aneurysm-epidemiology, predisposing factors, and biology.Langenbeck's archives of surgery · 2016Review
- Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients.International journal of medical sciences · 2016Article
- Micro RNA in Exosomes from HIV-Infected Macrophages.International journal of environmental research and public health · 2015Article
- The Role of MicroRNAs in Kidney Disease.Non-coding RNA · 2015Review
- Non-coding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment.Frontiers in genetics · 2015Review
- The microRNA miR-29a is associated with human immunodeficiency virus latency.Retrovirology · 2014Article
- Gamma-retroviral vector design for the co-expression of artificial microRNAs and therapeutic proteins.Nucleic acid therapeutics · 2014Article
- MicroRNAs differentially present in the plasma of HIV elite controllers reduce HIV infection in vitro.Scientific reports · 2014Article
- Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
Corrections and comments
- Retraction · 2012-08-29Error in Analyses · Error in Data · Error in Image ·
- Retracted
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Host cells respond to exogenous infectious agents such as viruses, including HIV-1. Studies have evaluated the changes associated with virus infection at the transcriptional and translational levels of the cellular genes involved in specific pathways. While this approach is useful, in our view it provides only a partial view of genome-wide changes. Recently, technological advances in the expression profiling at the microRNA (miRNA) and mRNA levels have made it possible to evaluate the changes in the components of multiple pathways. To understand the role of miRNA and its interplay with host cellular gene expression (mRNA) during HIV-1 infection, we performed a comparative global miRNA and mRNA microarray using human PBMCs infected with HIV-1. The PBMCs were derived from multiple donors and were infected with virus generated from the molecular clone pNL4-3. The results showed that HIV-1 infection led to altered regulation of 21 miRNAs and 444 mRNA more than 2-fold, with a statistical significance of p<0.05. Furthermore, the differentially regulated miRNA and mRNA were shown to be associated with host cellular pathways involved in cell cycle/proliferation, apoptosis, T-cell signaling, and immune activation. We also observed a number of inverse correlations of miRNA and mRNA expression in infected PBMCs, further confirming the interrelationship between miRNA and mRNA regulation during HIV-1 infection. These results for the first time provide evidence that the miRNA profile could be an early indicator of host cellular dysfunction induced by HIV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.