ArticlePLoS genetics2011
The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Mapping Fusarium wilt and sterility mosaic disease resistance-associated genomic regions and haplotype variants in pigeonpea.BMC plant biology · 2026Article
- Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans.Development (Cambridge, England) · 2025Article
- CDH-3/Cadherin, YAP-1/YAP and EGL-44/TEAD promote SYX-2/Syntaxin and EFF-1 fusogen-mediated phagosome closure.bioRxiv : the preprint server for biology · 2025Article
- Article
- UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Whole-body gene expression atlas of an adult metazoan.Science advances · 2023Article
- Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells.PLoS genetics · 2021Article
- Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID.Development (Cambridge, England) · 2021Article
- Increased expression of ANAC017 primes for accelerated senescence.Plant physiology · 2021Article
- Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans.Developmental biology · 2020Article
- A Cell Fate Switch in theGenetics · 2020Article
- How cells fuse.The Journal of cell biology · 2019Review
- Chromatin accessibility dynamics acrosseLife · 2018Article
- Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.PLoS biology · 2017Article
- Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions.Scientific reports · 2017Article
- Auto-fusion and the shaping of neurons and tubes.Seminars in cell & developmental biology · 2016Review
- RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.Cell reports · 2016Article
- The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.PLoS genetics · 2015Article
- Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters.Nucleic acids research · 2014Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 expression is directly regulated by the GATA factor ELT-1. elt-1(RNAi) animals display similar seam cell lineage defects to bro-1 mutants, but have an additional phenotype in which seam cells lose their stem cell-like properties and differentiate inappropriately by fusing with the hyp7 epidermal syncytium. This phenotype is dependent on the fusogen EFF-1, which we show is repressed by ELT-1 in seam cells. Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.