ArticlePLoS genetics2011
Quantitative and qualitative stem rust resistance factors in barley are associated with transcriptional suppression of defense regulons.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Neutral transcriptome rewiring promotes quantitative disease resistance evolvability at the species level.The Plant cell · 2025Article
- Polygenic pathogen networks influence transcriptional plasticity in the Arabidopsis-Botrytis pathosystem.Genetics · 2023Article
- Molecular mechanisms underpinning quantitative resistance toFrontiers in plant science · 2023Article
- A multigenotype maize silk expression atlas reveals how exposure-related stresses are mitigated following emergence from husk leaves.The plant genome · 2020Article
- Genomic basis of white pine blister rust quantitative disease resistance and its relationship with qualitative resistance.The Plant journal : for cell and molecular biology · 2020Article
- Robustness of plant quantitative disease resistance is provided by a decentralized immune network.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Rapid identification of an Arabidopsis NLR gene as a candidate conferring susceptibility to Sclerotinia sclerotiorum using time-resolved automated phenotyping.The Plant journal : for cell and molecular biology · 2020Article
- Development of Genome-Wide SNP Markers for Barley via Reference- Based RNA-Seq Analysis.Frontiers in plant science · 2019Article
- Contrasting nutrient-disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid.Plant, cell & environment · 2018Article
- Mapping adult plant stem rust resistance in barley accessions Hietpas-5 and GAW-79.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Genome-wide association study of stem rust resistance in a world collection of cultivated barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Time-course expression QTL-atlas of the global transcriptional response of wheat to Fusarium graminearum.Plant biotechnology journal · 2017Article
- Interchromosomal Transfer of Immune Regulation During Infection of Barley with the Powdery Mildew Pathogen.G3 (Bethesda, Md.) · 2017Article
- Genome-Wide Association Mapping of Stem Rust Resistance inG3 (Bethesda, Md.) · 2017Article
- Quantitative Resistance: More Than Just Perception of a Pathogen.The Plant cell · 2017Review
- Prior knowledge guided eQTL mapping for identifying candidate genes.BMC bioinformatics · 2016Article
- Isolation and fine mapping of Rps6: an intermediate host resistance gene in barley to wheat stripe rust.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- The Quantitative Basis of the Arabidopsis Innate Immune System to Endemic Pathogens Depends on Pathogen Genetics.PLoS genetics · 2016Article
- Genome-wide association study on stem rust resistance in Kazakh spring barley lines.BMC plant biology · 2016Article
- Genome-Editing Technologies for Enhancing Plant Disease Resistance.Frontiers in plant science · 2016Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Stem rust (Puccinia graminis f. sp. tritici; Pgt) is a devastating fungal disease of wheat and barley. Pgt race TTKSK (isolate Ug99) is a serious threat to these Triticeae grain crops because resistance is rare. In barley, the complex Rpg-TTKSK locus on chromosome 5H is presently the only known source of qualitative resistance to this aggressive Pgt race. Segregation for resistance observed on seedlings of the Q21861 × SM89010 (QSM) doubled-haploid (DH) population was found to be predominantly qualitative, with little of the remaining variance explained by loci other than Rpg-TTKSK. In contrast, analysis of adult QSM DH plants infected by field inoculum of Pgt race TTKSK in Njoro, Kenya, revealed several additional quantitative trait loci that contribute to resistance. To molecularly characterize these loci, Barley1 GeneChips were used to measure the expression of 22,792 genes in the QSM population after inoculation with Pgt race TTKSK or mock-inoculation. Comparison of expression Quantitative Trait Loci (eQTL) between treatments revealed an inoculation-dependent expression polymorphism implicating Actin depolymerizing factor3 (within the Rpg-TTKSK locus) as a candidate susceptibility gene. In parallel, we identified a chromosome 2H trans-eQTL hotspot that co-segregates with an enhancer of Rpg-TTKSK-mediated, adult plant resistance discovered through the Njoro field trials. Our genome-wide eQTL studies demonstrate that transcript accumulation of 25% of barley genes is altered following challenge by Pgt race TTKSK, but that few of these genes are regulated by the qualitative Rpg-TTKSK on chromosome 5H. It is instead the chromosome 2H trans-eQTL hotspot that orchestrates the largest inoculation-specific responses, where enhanced resistance is associated with transcriptional suppression of hundreds of genes scattered throughout the genome. Hence, the present study associates the early suppression of genes expressed in this host-pathogen interaction with enhancement of R-gene mediated resistance.
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