ArticlePLoS pathogens2011
A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.The Journal of experimental medicine · 2016Trial
- New Approaches to Tackling Intractable Issues in Infectious Disease.Microorganisms · 2024Review
- Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses.Frontiers in immunology · 2023Article
- Revisiting PersistentPathogens (Basel, Switzerland) · 2021Review
- Immune Modulation and the Development of Fowl Typhoid: A Model of Human Disease?Pathogens (Basel, Switzerland) · 2020Article
- Article
- Evolution of Salmonella within Hosts.Trends in microbiology · 2018Review
- Functional analysis of Salmonella Typhi adaptation to survival in water.Environmental microbiology · 2018Article
- Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease.Cell host & microbe · 2018Article
- Interspecies Hybridisation and Genome Chimerisation inFrontiers in microbiology · 2018Review
- Diagnostic metabolite biomarkers of chronic typhoid carriage.PLoS neglected tropical diseases · 2018Article
- Vaccination against Salmonella Infection: the Mucosal Way.Microbiology and molecular biology reviews : MMBR · 2017Review
- The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.PLoS pathogens · 2016Article
- Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen.PloS one · 2016Article
- The O-Antigen Capsule of Salmonella enterica Serovar Typhimurium Facilitates Serum Resistance and Surface Expression of FliC.Infection and immunity · 2015Article
- Now you see me, now you don't: the interaction of Salmonella with innate immune receptors.Nature reviews. Microbiology · 2015Review
- Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.PloS one · 2015Article
- The Vi capsular polysaccharide enables Salmonella enterica serovar typhi to evade microbe-guided neutrophil chemotaxis.PLoS pathogens · 2014Article
- Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation.PLoS pathogens · 2014Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The Vi capsular polysaccharide is a virulence-associated factor expressed by Salmonella enterica serotype Typhi but absent from virtually all other Salmonella serotypes. In order to study this determinant in vivo, we characterised a Vi-positive S. Typhimurium (C5.507 Vi(+)), harbouring the Salmonella pathogenicity island (SPI)-7, which encodes the Vi locus. S. Typhimurium C5.507 Vi(+) colonised and persisted in mice at similar levels compared to the parent strain, S. Typhimurium C5. However, the innate immune response to infection with C5.507 Vi(+) and SGB1, an isogenic derivative not expressing Vi, differed markedly. Infection with C5.507 Vi(+) resulted in a significant reduction in cellular trafficking of innate immune cells, including PMN and NK cells, compared to SGB1 Vi(-) infected animals. C5.507 Vi(+) infection stimulated reduced numbers of TNF-α, MIP-2 and perforin producing cells compared to SGB1 Vi(-). The modulating effect associated with Vi was not observed in MyD88(-/-) and was reduced in TLR4(-/-) mice. The presence of the Vi capsule also correlated with induction of the anti-inflammatory cytokine IL-10 in vivo, a factor that impacted on chemotaxis and the activation of immune cells in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.