ArticleJournal of Ayurveda and integrative medicine2010
Cyperus rotundus, a substitute for Aconitum heterophyllum: Studies on the Ayurvedic concept of Abhava Pratinidhi Dravya (drug substitution).
Article in Journal of Ayurveda and integrative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Population assessment and habitat suitability modelling of endangered medicinal plant, Aconitum heterophyllum Wall. ex Royle in the western Himalaya.Scientific reports · 2025Article
- GRAYU: graph-based database integrating Ayurvedic formulations, medicinal plants, phytochemicals and diseases.Frontiers in pharmacology · 2025Article
- Article
- Starch-based environment friendly, edible and antimicrobial films reinforced with medicinal plants.Frontiers in nutrition · 2022Article
- Therapeutic efficacy of the root tubers ofSaudi journal of biological sciences · 2020Article
- Review
- Estimating Herbal Product Authentication and Adulteration in India Using a Vouchered, DNA-Based Biological Reference Material Library.Drug safety · 2016Article
- Rasa Nirdhāraṇa (assessment of taste) of Leonotis nepetifolia (L.) R. Br.: A preliminary study in healthy volunteers.Ancient science of life · 2014Article
- Adaption and application of the four phase trials to traditional chinese medicines.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Hypolipidemic effect of methanol fraction of Aconitum heterophyllum wall ex Royle and the mechanism of action in diet-induced obese rats.Journal of advanced pharmaceutical technology & research · 2012Article
- Botanical identity of plant sources of Daśamūla drugs through an analysis of published literature.Ancient science of life · 2012Article
- Unani concept of drug substitution (therapeutic interchange) and its validation on scientific parameters.Journal of Ayurveda and integrative medicineArticle
- Review of unique ophthalmic formulations in Vaidya Manorama: A traditional Kerala Ayurveda literature.Journal of Ayurveda and integrative medicineReview
- Plant parts substitution based approach as a viable conservation strategy for medicinal plants: A case study of Premna latifolia Roxb.Journal of Ayurveda and integrative medicineArticle
- Pharmacology of Ativisha, Musta and their substitutes.Journal of Ayurveda and integrative medicineReview
- Antisecretory and antimotility activity of Aconitum heterophyllum and its significance in treatment of diarrhea.Indian journal of pharmacologyArticle
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3 authors.
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Abstract
In the absence of a desired first choice medicinal herb, classical Ayurveda recommends use of a functionally similar substitute. Post 16th century Ayurvedic texts and lexicons give specific examples of possible substitutes. Here we report a preliminary study of one such Ayurvedic substitution pair: Musta (Cyperus rotundus L., Cyperaceae), a common weed, for the rare Himalayan species, Ativisha (Aconitum heterophyllum Wall. ex Royle; Ranunculaceae). The study's strategy was to use modern phytochemical and pharmacological methods to test the two herbs for biochemical and metabolic similarities and differences, and literary studies to compare their Ayurvedic properties, a novel trans-disciplinary approach. No previous scientific paper has compared the two herbs' bioactivities or chemical profiles. Despite being taxonomically unrelated, the first choice, but relatively unavailable (Abhava) plant, A. heterophyllum, and its substitute (Pratinidhi) C. rotundus, are not only similar in Ayurvedic pharmacology (Dravyaguna) profile, but also in phytochemical and anti-diarrheal properties. These observations indicate that Ayurveda may attach more importance to pharmacological properties of raw drugs than to their botanical classification. Further research into the nature of raw drugs named could open up new areas of medicinal plant classification, linking chemistry and bioactivity. Understanding the logic behind the Ayurvedic concept of Abhava Pratinidhi Dravya (drug substitution) could lead to new methods of identifying legitimate drug alternatives, and help solve industry's problems of crude drug shortage.
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