ArticleEuropean journal of human genetics : EJHG2012
People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation.Arthritis research & therapy · 2015Pooled it
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- The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.Communications biology · 2023Article
- Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK.PLoS genetics · 2023Article
- British surname origins, population structure and health outcomes-an observational study of hospital admissions.Scientific reports · 2022Observational
- Phylogeographic review of Y chromosome haplogroups in Europe.International journal of legal medicine · 2021Review
- Y chromosome analysis for common surnames in the Japanese male population.Journal of human genetics · 2021Article
- Surname affinity in Santiago, Chile: A network-based approach that uncovers urban segregation.PloS one · 2021Article
- The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.Frontiers in genetics · 2019Review
- Genetics of the human face: Identification of large-effect single gene variants.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.Scientific reports · 2017Article
- Fine-Scale Genetic Structure in Finland.G3 (Bethesda, Md.) · 2017Article
- Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions.Scientific reports · 2017Article
- Genomic insights into the population structure and history of the Irish Travellers.Scientific reports · 2017Article
- A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Regional surnames and genetic structure in Great Britain.Transactions (Institute of British Geographers : 1965) · 2016Article
- Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.Annals of neurology · 2016Article
- Iron Age and Anglo-Saxon genomes from East England reveal British migration history.Nature communications · 2016Article
- Population Dynamics of Early Human Migration in Britain.PloS one · 2016Article
- The relationship between surname frequency and Y chromosome variation in Spain.European journal of human genetics : EJHG · 2016Article
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31 authors at 16 institutions in 1 country.
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Abstract
There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.