Trial reportBritish journal of cancer2011
Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields.
Trial report in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03037840 (Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients In Vivo), which is not on this map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients In Vivo
Who cites it
43 citing papers in PubMed, 108 citations in OpenAlex.
- Low-energy amplitude-modulated electromagnetic field exposure: Feasibility study in patients with hepatocellular carcinoma.Cancer medicine · 2023Trial
- Beyond Tumor Treating Fields: Multimodal Antitumor Action and the Clinical Potential of Pulsed Electromagnetic Fields.Current medical science · 2026Review
- Article
- Therapeutic Magnetic Fields in Oncology: A Systematic Review of Safety and Supportive Clinical Use.Cureus · 2026Review
- Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields.Oncotarget · 2025Article
- Detection of the characteristic magnetic signal of paclitaxel and its application in the inhibition of glioma cells.Fundamental research · 2025Article
- Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers.Molecular cancer · 2025Review
- Low-frequency magnetic field therapy for glioblastoma: Current advances, mechanisms, challenges and future perspectives.Journal of advanced research · 2025Review
- U.S. policy on wireless technologies and public health protection: regulatory gaps and proposed reforms.Frontiers in public health · 2025Review
- [Effects of Electromagnetic Pulses on Exosomes Secretion by A549 Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- A new tumor-treating device OM-100 with low-frequency magnetic fields inhibits proliferation and metastasis in liver cancer.BMC cancer · 2024Article
- Article
- Thermodynamic Considerations on the Biophysical Interaction between Low-Energy Electromagnetic Fields and Biosystems.Membranes · 2024Article
- The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets.International journal of molecular sciences · 2024Article
- Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.Frontiers in network physiology · 2024Review
- Tumor treating induced fields: a new treatment option for patients with glioblastoma.Frontiers in neurology · 2024Article
- Pulsed Electromagnetic Fields (PEMF)-Physiological Response and Its Potential in Trauma Treatment.International journal of molecular sciences · 2023Review
- Prevalence of Migraine Disease in Electrohypersensitive Patients.Journal of clinical medicine · 2023Article
- Comparison of the Performance of Bioresonance, Electrophoresis and RT-PCR in the Diagnosis of Feline Infectious Peritonitis.Archives of Razi Institute · 2023Article
- Combined effects of EMP and RF field on emotional behavior in mice.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTherapeutic options for patients with advanced hepatocellular carcinoma (HCC) are limited. There is emerging evidence that the growth of cancer cells may be altered by very low levels of electromagnetic fields modulated at specific frequencies.
methodsA single-group, open-label, phase I/II study was performed to assess the safety and effectiveness of the intrabuccal administration of very low levels of electromagnetic fields amplitude modulated at HCC-specific frequencies in 41 patients with advanced HCC and limited therapeutic options. Three-daily 60-min outpatient treatments were administered until disease progression or death. Imaging studies were performed every 8 weeks. The primary efficacy end point was progression-free survival 6 months. Secondary efficacy end points were progression-free survival and overall survival.
resultsTreatment was well tolerated and there were no NCI grade 2, 3 or 4 toxicities. In all, 14 patients (34.1%) had stable disease for more than 6 months. Median progression-free survival was 4.4 months (95% CI 2.1-5.3) and median overall survival was 6.7 months (95% CI 3.0-10.2). There were three partial and one near complete responses.
conclusionTreatment with intrabuccally administered amplitude-modulated electromagnetic fields is safe, well tolerated, and shows evidence of antitumour effects in patients with advanced HCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.