ReviewMolecular therapy : the journal of the American Society of Gene Therapy2011
Insulin-producing surrogate β-cells from embryonic stem cells: are we there yet?
Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- State of the Art of Bioengineering Approaches in Beta-Cell Replacement.Current transplantation reports · 2025Review
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- Review
- Notch1 Has an Important Role in β-Cell Mass Determination and Development of Diabetes.Diabetes & metabolism journal · 2021Article
- Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture.Scientific reports · 2019Article
- Establishment of Insulin-Producing Cells From Human Embryonic Stem Cells Underhypoxic Condition for Cell Based Therapy.Frontiers in cell and developmental biology · 2018Article
- Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo.Scientific reports · 2016Article
- A Quick and Efficient Method for the Purification of Endoderm Cells Generated from Human Embryonic Stem Cells.Journal of visualized experiments : JoVE · 2016Article
- Approaching a cure for type 1 diabetes.Nature medicine · 2016Article
- In Vitro Differentiation of Insulin Secreting Cells from Mouse Bone Marrow Derived Stage-Specific Embryonic Antigen 1 Positive Stem Cells.Cell journal · 2016Article
- Diabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives.World journal of diabetes · 2014Review
- The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling.Stem cell reviews and reports · 2014Article
- In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.The review of diabetic studies : RDS · 2014Review
- Functions and roles of proteins: diabetes as a paradigm.Progress in biophysics and molecular biology · 2014Review
- MicroRNA target sites as genetic tools to enhance promoter-reporter specificity for the purification of pancreatic progenitor cells from differentiated embryonic stem cells.Stem cell reviews and reports · 2013Article
- The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.Journal of cell science · 2013Article
- Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.Development (Cambridge, England) · 2013Article
- Stem cell therapy: an exercise in patience and prudence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- A critical re-evaluation of CD24-positivity of human embryonic stem cells differentiated into pancreatic progenitors.Stem cell reviews and reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem cells (ESCs) harbor the potential to generate every cell type of the body by differentiation. The use of hESCs holds great promise for potential cell replacement therapies for degenerative diseases including diabetes mellitus. The recently discovered induced pluripotent stem cells (iPSCs) exhibit immense potential for regenerative medicine as they allow the generation of autologous cells tailored to the patients' immune system. Research for insulin-producing surrogate cells from ESCs has yielded highly controversial results, because many steps and factors in the differentiation process are currently still unknown. Thus, there is no consensus on common standard protocols. The protocols presently used established the differentiation from pluripotent cells toward pancreatic progenitor cells. However, none of the differentiation protocols reported to date have generated by exclusive in vitro differentiation sufficient numbers of insulin-producing cells meeting all essential criteria of a β-cell. The cells often lack the crucial function of regulated insulin secretion upon glucose stimulation. This review focuses on past and current approaches to the generation of insulin-producing cells from pluripotent sources, such as ESCs and iPSCs, and critically discusses the hurdles to be taken before insulin-secreting surrogate cells derived from these stem cells will be of clinical use in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.