Trial reportInfection control and hospital epidemiology2011
Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial.
Trial report in Infection control and hospital epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00513799 (The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and an Evaluation of Decolonization Strategies
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Pooled it
- Interventions for the prevention of recurrent erysipelas and cellulitis.The Cochrane database of systematic reviews · 2017Pooled it
- The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2013Pooled it
- Trial
- HOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection-A Randomized Clinical Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- The Skin Microbiome of Patients With Atopic Dermatitis Normalizes Gradually During Treatment.Frontiers in cellular and infection microbiology · 2021Trial
- Frequent use of chlorhexidine-based body wash associated with a reduction in methicillin-resistant Staphylococcus aureus nasal colonization among military trainees.Antimicrobial agents and chemotherapy · 2015Trial
- Hygiene strategies to prevent methicillin-resistant Staphylococcus aureus skin and soft tissue infections: a cluster-randomized controlled trial among high-risk military trainees.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Trial
- Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S aureus skin and soft tissue infections.The Journal of pediatrics · 2014Trial
- Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections.Antimicrobial agents and chemotherapy · 2013Trial
- Past, Present, and Future of Sodium Hypochlorite in Dermatology: A Scoping Review.American journal of clinical dermatology · 2026Article
- Fluoroquinolone resistance without fluoroquinolone use; the genie is truly out of the bottle.Frontiers in microbiology · 2026Review
- Evaluating bias in electronic health record data: using agent-based models to examine whether geographic disparities in community-acquired methicillin-resistant Staphylococcus aureus are due to differential health care-seeking behaviors.American journal of epidemiology · 2025Article
- Hypochlorous Acid: Clinical Insights and Experience in Dermatology, Surgery, Dentistry, Ophthalmology, Rhinology, and Other Specialties.Biomedicines · 2025Review
- The Influence of Maternal Staphylococcus aureus Anti-Hla Neutralizing Antibody on Infant Skin and Soft Tissue Development in the First Year of Life.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Recurrent skin and soft tissue infections (SSTIs) in three family members caused by methicillin-resistantBMJ case reports · 2024Article
- Community-acquired Staphylococcus aureus skin and soft tissue infection risk assessment using hotspot analysis and risk maps: the case of California emergency departments.BMC public health · 2024Article
- Inborn Errors of Immunity and Efforts to Diagnose Affected Children in the Absence of Training and Specialty Practice in Clinical Immunology in Ethiopia: a Brief Report.Journal of clinical immunology · 2023Article
- Comparison of antibiofilm activity of low-concentrated hypochlorites vs polyhexanide-containing antiseptic.Frontiers in cellular and infection microbiology · 2023Article
- Longitudinal Dynamics of Skin Bacterial Communities in the Context of Staphylococcus aureus Decolonization.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite a paucity of evidence, decolonization measures are prescribed for outpatients with recurrent Staphylococcus aureus skin and soft-tissue infection (SSTI).
objectiveCompare the effectiveness of 4 regimens for eradicating S. aureus carriage.
designOpen-label, randomized controlled trial. Colonization status and recurrent SSTI were ascertained at 1 and 4 months.
settingBarnes-Jewish and St. Louis Children's Hospitals, St. Louis, Missouri, 2007-2009.
participantsThree hundred patients with community-onset SSTI and S. aureus colonization in the nares, axilla, or inguinal folds.
interventionsParticipants were randomized to receive no therapeutic intervention (control subjects) or one of three 5-day regimens: 2% mupirocin ointment applied to the nares twice daily, intranasal mupirocin plus daily 4% chlorhexidine body washes, or intranasal mupirocin plus daily dilute bleach water baths.
resultsAmong 244 participants with 1-month colonization data, modified intention-to-treat analysis revealed S. aureus eradication in 38% of participants in the education only (control) group, 56% of those in the mupirocin group (P = .03 vs controls), 55% of those in the mupirocin and chlorhexidine group (P = .05), and 63% off those in the mupirocin and bleach group (P = .006). Of 229 participants with 4-month colonization data, eradication rates were 48% in the control group, 56% in the mupirocin only group (P = .40 vs controls), 54% in the mupirocin and chlorhexidine group (P = .51), and 71% in the mupirocin and bleach group (P = .02). At 1 and 4 months, recurrent SSTIs were reported by 20% and 36% of participants, respectively.
conclusionsAn inexpensive regimen of dilute bleach baths, intranasal mupirocin, and hygiene education effectively eradicated S. aureus over a 4-month period. High rates of recurrent SSTI suggest that factors other than endogenous colonization are important determinants of infection. Trial registration. ClinicalTrials.gov identifier: NCT00513799.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.