ArticleAmerican journal of epidemiology2011
Body size in early life and adult levels of insulin-like growth factor 1 and insulin-like growth factor binding protein 3.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Early-life body mass index and risks of breast, endometrial, and ovarian cancers: a dose-response meta-analysis of prospective studies.British journal of cancer · 2022Pooled it
- Age at First Pregnancy, Adult Weight Gain and Postmenopausal Breast Cancer Risk: The PROCAS Study (United Kingdom).International journal of cancer · 2026Article
- Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.British journal of cancer · 2025Article
- Associations of early-adulthood adiposity with breast parenchymal tissue complexity within premenopausal women.Breast cancer research : BCR · 2025Article
- Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women.Breast cancer research : BCR · 2025Article
- The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause.Carcinogenesis · 2025Article
- Prospective Analysis of Circulating Biomarkers and Ovarian Cancer Risk in the UK Biobank.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Lignan Intake and Type 2 Diabetes Incidence Among US Men and Women.JAMA network open · 2024Article
- Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.British journal of cancer · 2024Article
- Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Association of early menarche with breast tumor molecular features and recurrence.Breast cancer research : BCR · 2024Article
- Divergent Selection in Low Recombination Regions Shapes the Genomic Islands in Two Incipient Shorebird Species.Molecular biology and evolution · 2024Article
- Trauma, psychological distress and markers of systemic inflammation among US women: A longitudinal study.Psychoneuroendocrinology · 2022Article
- Birth weight and long-term risk of mortality among US men and women: Results from three prospective cohort studies.Lancet regional health. Americas · 2022Article
- Changes in adiposity over the life course and gene expression in postmenopausal women.Cancer medicine · 2022Article
- Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.Communications biology · 2022Article
- Dietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome.BMC microbiology · 2022Article
- Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan.BMC cancer · 2022Article
- Article
- Early-Life Body Adiposity and the Breast Tumor Transcriptome.Journal of the National Cancer Institute · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Body size in early life has been associated with breast cancer risk. This may be partly mediated through the insulin-like growth factor (IGF) pathway. The authors assessed whether birth weight, body fatness at ages 5 and 10 years, and body mass index (BMI; weight (kg)/height (m)(2)) at age 18 years were associated with plasma concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 in 6,520 women aged 32-70 years at blood draw from the Nurses' Health Study (1990-2006) and Nurses' Health Study II (1997-2005). Birth weight, body fatness in childhood, and BMI at age 18 years were inversely associated with adult IGF-1 levels. For example, IGF-1 levels were 11.9% lower in women who reported being heaviest at age 10 years than in those who were leanest at age 10 (P-trend < 0.0001). Further, women who reported their birth weight as ≥10 pounds (≥4.5 kg) (vs. <5.5 pounds (<2.5 kg)) had 7.9% lower IGF-1 levels (P-trend = 0.002). Women whose BMI at age 18 years was ≥30 (vs. <20) had 14.1% lower IGF-1 levels (P-trend < 0.0001). Similar inverse associations were observed for insulin-like growth factor binding protein 3. These observations did not vary by adult BMI or menopausal status at blood draw. These findings suggest that altered IGF-1 levels in adulthood may be a mechanism through which early-life body size influences subsequent breast cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.