ArticleAmerican journal of epidemiology2011
Methods for characterizing differences in longitudinal glomerular filtration rate changes between children with glomerular chronic kidney disease and those with nonglomerular chronic kidney disease.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- The epidemiology of kidney and urinary tract infections in pediatric chronic kidney disease: prevalence, risk factors and association with GFR decline in the Chronic Kidney Disease in Children Study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Longitudinal progression trajectory of estimated glomerular filtration rate in children with chronic kidney disease: results from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease).Kidney research and clinical practice · 2025Article
- FEVThe European respiratory journal · 2024Article
- AbioRxiv : the preprint server for biology · 2024Article
- Development of an adaptive clinical web-based prediction tool for kidney replacement therapy in children with chronic kidney disease.Kidney international · 2023Article
- Data quality control in longitudinal epidemiologic studies: conditional studentized residuals from linear mixed effects models for outlier detection in the setting of pediatric chronic kidney disease.Annals of epidemiology · 2023Article
- Associations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2023Article
- Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD.Scientific reports · 2023Article
- Kidney Disease Progression in Children and Young Adults With Pediatric CKD: Epidemiologic Perspectives and Clinical Applications.Seminars in nephrology · 2021Review
- Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort.Hypertension (Dallas, Tex. : 1979) · 2021Observational
- Timing of patient-reported renal replacement therapy planning discussions by disease severity among children and young adults with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Low Serum Bicarbonate and CKD Progression in Children.Clinical journal of the American Society of Nephrology : CJASN · 2020Article
- Association of Time-Varying Blood Pressure With Chronic Kidney Disease Progression in Children.JAMA network open · 2020Article
- Nonparametric Assessment of Differences Between Competing Risk Hazard Ratios: Application to Racial Differences in Pediatric Chronic Kidney Disease Progression.Clinical epidemiology · 2020Article
- Incidence of Initial Renal Replacement Therapy Over the Course of Kidney Disease in Children.American journal of epidemiology · 2019Observational
- Short stature in advanced pediatric CKD is associated with faster time to reduced kidney function after transplant.Pediatric nephrology (Berlin, Germany) · 2019Article
- Cardiometabolic Risk Factors, Metabolic Syndrome, and Chronic Kidney Disease Progression in Children.The Journal of pediatrics · 2018Article
- Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease.Annals of epidemiology · 2018Article
- Racial differences in renal replacement therapy initiation among children with a nonglomerular cause of chronic kidney disease.Annals of epidemiology · 2016Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The rate of decline of glomerular filtration rate (GFR) in children with chronic kidney disease (CKD) can vary, even among those with similar diagnoses. Classic regression methods applied to the log-transformed GFR (i.e., lognormal) quantify only rigid shifts in a given outcome. The generalized gamma distribution offers an alternative approach for characterizing the heterogeneity of effect of an exposure on a positive, continuous outcome. Using directly measured GFR longitudinally assessed between 2005 and 2010 in 529 children enrolled in the Chronic Kidney Disease in Children Study, the authors characterized the effect of glomerular CKD versus nonglomerular CKD diagnoses on the outcome, measured as the annualized GFR ratio. Relative percentiles were used to characterize the heterogeneity of effect of CKD diagnosis across the distribution of the outcome. The rigid shift assumed by the classic mixed models failed to capture the fact that the greatest difference between the glomerular and nonglomerular diagnosis' annualized GFR ratios was in children who exhibited the fastest GFR declines. Although this difference was enhanced in children with an initial GFR level of 45 mL/minute/1.73 m(2) or less, the effect of diagnosis on outcome was not significantly modified by level. Generalized gamma models captured heterogeneity of effect more richly and provided a better fit to the data than did conventional lognormal models.
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