Evidence map›Paper›PMID 21828266›Full record

ArticleGenes & development2011

A snRNP's ordered path to maturity.

Saba Valadkhan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Saba ValadkhanCenter for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. saba.valadkhan@case.edu
Case Western Reserve University · US

Funding

Characterization of a minimal "spliceosome"R01GM078572 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI VALADKHAN, SABA · 2006 to 2010
$1.5M
NIGMS NIH HHS GM078572NIGMS NIH HHS R01 GM078572
6 · The paper itself

Abstract

The U5 snRNP (small ribonucleoprotein) contains several functionally crucial splicing factors that form an extensive interaction network both in the snRNP and within the spliceosome. In this issue of Genes & Development, Weber and colleagues (pp. 1601-1612) shed light on the dynamic assembly of this critical spliceosomal component and elucidate the molecular interactions underlying the ordered addition of Brr2, a pivotal spliceosomal helicase, to the U5 snRNP.

Indexed as

HumansNuclear ProteinsPhosphorylationRetinitis PigmentosaRibonucleoprotein, U4-U6 Small NuclearRibonucleoprotein, U5 Small NuclearRNA HelicasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpliceosomesAar2p protein, S cerevisiaeBRR2 protein, S cerevisiaeNuclear ProteinsPRP8 protein, S cerevisiaeRibonucleoprotein, U4-U6 Small NuclearRibonucleoprotein, U5 Small NuclearRNA HelicasesSaccharomyces cerevisiae Proteins

Identifiers

PMID21828266
PMCPMC3182023
OpenAlexW2150340438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.