ArticleDevelopment (Cambridge, England)2011
Motoneurons are essential for vascular pathfinding.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Plexin D1 negatively regulates zebrafish lymphatic development.Development (Cambridge, England) · 2022Article
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- Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos.Scientific reports · 2022Article
- Anatomy and development of the pectoral fin vascular network in the zebrafish.Development (Cambridge, England) · 2022Article
- Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021Review
- Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis.Nature communications · 2020Article
- Quantification of Angiogenesis and Lymphangiogenesis in the Dual ex vivo Aortic and Thoracic Duct Assay.Protein and peptide letters · 2020Article
- Lymphangiogenesis guidance by paracrine and pericellular factors.Genes & development · 2017Review
- Knockdown of Laminin gamma-3 (Lamc3) impairs motoneuron guidance in the zebrafish embryo.Wellcome open research · 2017Article
- Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development.Development (Cambridge, England) · 2015Article
- Junb controls lymphatic vascular development in zebrafish via miR-182.Scientific reports · 2015Article
- Article
- The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish.Development (Cambridge, England) · 2013Article
- Branching morphogenesis: from cells to organs and back.Cold Spring Harbor perspectives in biology · 2012Review
- lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish.Development (Cambridge, England) · 2012Article
- Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature.Developmental cell · 2012Article
- Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.Development (Cambridge, England) · 2012Article
- olig2-Expressing hindbrain cells are required for migrating facial motor neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The neural and vascular systems share common guidance cues that have direct and independent signaling effects on nerves and endothelial cells. Here, we show that zebrafish Netrin 1a directs Dcc-mediated axon guidance of motoneurons and that this neural guidance function is essential for lymphangiogenesis. Specifically, Netrin 1a secreted by the muscle pioneers at the horizontal myoseptum (HMS) is required for the sprouting of dcc-expressing rostral primary motoneuron (RoP) axons and neighboring axons along the HMS, adjacent to the future trajectory of the parachordal chain (PAC). These axons are required for the formation of the PAC and, subsequently, the thoracic duct. The failure to form the PAC in netrin 1a or dcc morphants is phenocopied by laser ablation of motoneurons and is rescued both by cellular transplants and overexpression of dcc mRNA. These results provide a definitive example of the requirement of axons in endothelial guidance leading to the parallel patterning of nerves and vessels in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.