ArticleNeuroImage2012
Relationship between aberrant brain connectivity and clinical features in Angelman Syndrome: a new method using tract based spatial statistics of DTI color-coded orientation maps.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03358823 (Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Cortical and subcortical morphological alteration in Angelman syndrome.Journal of neurodevelopmental disorders · 2023Article
- Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome.Molecular autism · 2021Article
- Evaluation of a TrkB agonist on spatial and motor learning in theLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Disrupted Functional and Structural Connectivity in Angelman Syndrome.AJNR. American journal of neuroradiology · 2020Article
- The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.Molecular autism · 2019Article
- Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome.Brain and cognition · 2018Article
- Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study.Molecular autism · 2018Article
- Autism spectrum disorder: neuropathology and animal models.Acta neuropathologica · 2017Review
- Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Relationship between genotype and arcuate fasciculus morphology in six young children with global developmental delay: Preliminary DTI stuy.Journal of magnetic resonance imaging : JMRI · 2016Article
- Differentiation of Speech Delay and Global Developmental Delay in Children Using DTI Tractography-Based Connectome.AJNR. American journal of neuroradiology · 2016Article
- Article
- Allelic specificity of Ube3a expression in the mouse brain during postnatal development.The Journal of comparative neurology · 2014Article
- Disruption of the LTD dialogue between the cerebellum and the cortex in Angelman syndrome model: a timing hypothesis.Frontiers in systems neuroscience · 2014Article
- The dual loop model: its relation to language and other modalities.Frontiers in evolutionary neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimIn order to relate brain structural abnormalities to clinical features of Angelman Syndrome (AS), we determined the locations of abnormal regional white matter architecture in AS children using a sensitive and objective whole brain approach to analyze diffusion tensor imaging (DTI) color-coded orientation maps.
methodsUsing tract based spatial statistics (TBSS) of DTI color-coded orientation maps, the fraction of fibers oriented in the anteroposterior (AP), mediolateral (ML) and superioinferior (SI) directions were determined in whole brain white matter of 7 children with AS (mean age: 70±25.78 months, 5 males) and 7 children with typical development (TD, mean age: 79.8±17.25 months, 4 males). TBSS of FA map was also performed for comparison.
resultsChildren with AS had a significantly lower AP component than the TD group in 9 clusters (3 bilateral and 3 unilateral). Bilateral clusters were located in inferior fronto-occipital fasciculus, anterior thalamic radiation and arcuate fasciculus regions. Unilateral clusters involved left brainstem, left cingulum and right uncinate regions. Similarly, children with AS had significantly lower ML component than the TD group in 4 clusters (2 in corpus callosum and 2 unilateral clusters). Unilateral clusters were located in the left cingulum and left anterior thalamic radiation regions. SI component was lower in children with AS in two clusters compared to TD (corticospinal tract and corpus callosum). FA map clusters mostly corresponded with component clusters.
interpretationChildren with AS have a global impairment of white matter integrity including AP, ML and SI components in whole brain suggesting a potential underlying error with axon guidance mechanisms during brain development possibly due to loss of UBE3A gene expression. Some of this aberrant connectivity can be related to the clinical features of AS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.