ReviewMolecular and cellular endocrinology2012
The paracrinology of tubal ectopic pregnancy.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review.Biology of reproduction · 2023Pooled it
- Relation of Chlamydia trachomatis infections to ectopic pregnancy: A meta-analysis and systematic review.Medicine · 2020Pooled it
- Article
- [Evaluation ofZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Heterotopic pregnancy following ovulation induction with clomiphene citrate therapy: A case report.Case reports in women's health · 2025Article
- Twin interstitial ectopic pregnancy following ipsilateral tubal pregnancy: a case report.Journal of medical case reports · 2025Article
- The Effect of AlteredInternational journal of fertility & sterility · 2023Article
- Comparison of the application value of transvaginal ultrasound and transabdominal ultrasound in the diagnosis of ectopic pregnancy.World journal of clinical cases · 2023Article
- Mechanism of Human Tubal Ectopic Pregnancy Caused by Cigarette Smoking.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy.International journal of molecular sciences · 2022Review
- Article
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis.International journal of molecular sciences · 2016Article
- Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study.Reproductive biology and endocrinology : RB&E · 2015Article
- Role of Chlamydia trachomatis and emerging Chlamydia-related bacteria in ectopic pregnancy in Vietnam.Epidemiology and infection · 2015Article
- Molecular Regulation of Parturition: The Role of the Decidual Clock.Cold Spring Harbor perspectives in medicine · 2015Review
- Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review.Fertility research and practice · 2015Review
- Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review.Reproductive biology and endocrinology : RB&E · 2014Article
- The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian tube.International journal of clinical and experimental pathology · 2014Article
- The expression of IL-6Rα and Gp130 in fallopian tubes bearing an ectopic pregnancy.Anatomy & cell biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
As part of successful human reproduction, the Fallopian tube must provide a suitable environment for pre-implantation development of the embryo and for efficient transport of the embryo to the uterus for implantation. These functions are coordinated by paracrine interactions between tubal epithelial, smooth muscle and immune cells and the cells of the developing embryo. Alterations in these signals can lead to a tubal microenvironment encouraging of embryo implantation and to dysregulated tubal motility, ultimately resulting in inappropriate and early implantation of the embryo in the Fallopian tube. Here, we highlight novel and emerging concepts in tubal physiology and pathobiology, such as the induction of a receptive phenotype within the Fallopian tube, leading to ectopic implantation. Chlamydia trachomatis infection is a risk factor for tubal ectopic pregnancy. Activation of toll-like receptor 2 (TLR-2) in the Fallopian tube epithelium, by C. trachomatis has recently been demonstrated, leading to the dysregulation of factors involved in implantation and smooth muscle contractility, such as prokineticins (PROK), activin A and interleukin 1 (IL-1). The Fallopian tube has also recently been shown to harbour a unique population of immune cells, compared to the endometrium. In addition, the complement of immune cells in the Fallopian tube has been reported to be altered in Fallopian tube from women with ectopic pregnancy. There are increasing data suggesting that vascularisation of the Fallopian tube, by the embryo during ectopic pregnancy, differs from that initiated in the uterus during normal pregnancy. This too, is likely the result of paracrine signals between the embryo and the tubal microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.