ArticleBMC infectious diseases2011
Prognostic factors related to sequelae in childhood bacterial meningitis: data from a Greek meningitis registry.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Shorter versus longer duration of antibiotic treatment in children with bacterial meningitis: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Risk factors associated with the outcomes of pediatric bacterial meningitis: a systematic review.Jornal de pediatriaPooled it
- From Presentation to Prognosis: Case-Based Learning in Pediatric Bacterial Meningitis for Postgraduate Training.MedEdPORTAL : the journal of teaching and learning resources · 2026Article
- The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with Community-Acquired Bacterial Meningitis Receiving Vancomycin: A Ten-Year Retrospective Cohort Study.Infectious diseases and therapy · 2025Article
- Clinical features and long-term outcomes of children with pneumococcal meningitis in China: a 10-year single-centre retrospective analysis.BMC pediatrics · 2025Article
- Identifying the need for surgical intervention in pediatric bacterial meningitis: single-center experience.Frontiers in pediatrics · 2025Article
- Pediatric bacterial meningitis in southern China: analysis of 838 cases.Frontiers in cellular and infection microbiology · 2025Article
- The effect of machine learning algorithms in the prediction, and diagnosis of meningitis: A systematic review.Health science reports · 2024Review
- Clinical analysis of hyperbaric oxygen combined with subdural drilling and drainage in the management of subdural effusion type IV with intracranial infection in infant patients.Frontiers in neurology · 2024Article
- High-risk factors associated with refractory childhood bacterial meningitis in Southwest China.BMC pediatrics · 2023Article
- Clinical and laboratory profile of patients with presumptive clinical diagnosis of acute bacterial meningitis and its short-term complications.Journal of family medicine and primary care · 2022Article
- Neutrophil lymphocyte ratio as predictor of mortality in pediatric patients with bacterial meningitis: A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
- Cerebrospinal fluid changes and clinical features of aseptic meningitis in patients with Kawasaki disease.The Journal of international medical research · 2021Article
- Prevalence and risk factors of seizure in children with acute bacterial meningitis: updating previous evidence using an epidemiological design.Iranian journal of child neurology · 2021Article
- CD48 and α7 Nicotinic Acetylcholine Receptor Synergistically Regulate FimH-Mediated Escherichia coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells.The Journal of infectious diseases · 2019Article
- Cerebrospinal fluid protein and glucose levels in neonates with a systemic inflammatory response without meningitis.Fluids and barriers of the CNS · 2018Article
- Neurological Complications in Young Infants With Acute Bacterial Meningitis.Frontiers in neurology · 2018Article
- Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.Scientific reports · 2017Article
- A Case-Control Study on the Risk Factors for Meningococcal Disease among Children in Greece.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial meningitis (BM) is a life-threatening disease, often related with serious complications and sequelae. Infants and children who survive bacterial meningitis often suffer neurological and other sequelae.
methodsA total of 2,477 patients aged 1 month to 14 years old hospitalized in a Children's Hospital in Greece diagnosed with acute bacterial meningitis were collected through a Meningitis Registry, from 1974 to 2005. Clinical, laboratory and other parameters (sex, age, pathogen, duration of symptoms before and after admission) were evaluated through univariate and multivariate analysis with regard to sequelae. Analysis of acute complications were also studied but not included in the final model.
resultsThe rate of acute complications (arthritis and/or subdural effusion) was estimated at 6.8% (152 out of 2,251 patients, 95%CI 5.8-7.9) while the rate of sequelae (severe hearing loss, ventriculitis, hydrocephalus or seizure disorder) among survivors was estimated at 3.3% (73 out of 2,207 patients, 95%CI 2.6-4.2). Risk factors on admission associated with sequelae included seizures, absence of hemorrhagic rash, low CSF glucose, high CSF protein and the etiology of meningitis. A combination of significant prognostic factors including presence of seizures, low CSF glucose, high CSF protein, positive blood culture and absence of petechiae on admission presented an absolute risk of sequelae of 41.7% (95%CI 15.2-72.3).
conclusionsA combination of prognostic factors of sequelae in childhood BM may be of value in selecting patients for more intensive therapy and in identifying possible candidates for new treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.