ReviewNeurocritical care2011
Summary of evidence on immediate statins therapy following aneurysmal subarachnoid hemorrhage.
Review in Neurocritical care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Statins Improve Clinical Outcome After Non-aneurysmal Subarachnoid Hemorrhage: A Translational Insight From a Systematic Review of Experimental Studies.Frontiers in neurology · 2021Pooled it
- The Relationship Between Smoking and Delayed Cerebral Ischemia After Intracranial Aneurysm Rupture: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Effects of statins-use for patients with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials.Scientific reports · 2014Pooled it
- Long-acting statin for aneurysmal subarachnoid hemorrhage: A randomized, double-blind, placebo-controlled trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Trial
- The Landscape of Randomized Clinical Trial Meta-analyses on Statins for Aneurysmal Subarachnoid Hemorrhage: A Scoping Review.CNS & neurological disorders drug targets · 2024Article
- Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia.Expert review of neurotherapeutics · 2016Review
- The critical care management of poor-grade subarachnoid haemorrhage.Critical care (London, England) · 2016Article
- Beta Blockade and Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage.The open neurology journal · 2016Article
- Encephalic hemodynamic phases in subarachnoid hemorrhage: how to improve the protective effect in patient prognoses.Neural regeneration research · 2015Review
- Principles of neuroanesthesia in aneurysmal subarachnoid hemorrhage.Journal of anaesthesiology, clinical pharmacology · 2014Review
- Current management of delayed cerebral ischemia: update from results of recent clinical trials.Translational stroke research · 2014Review
- Delayed neurological deterioration after subarachnoid haemorrhage.Nature reviews. Neurology · 2014Review
- The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment.Journal of neurosurgery · 2013Article
- Suppression of the Rho/Rho-kinase pathway and prevention of cerebral vasospasm by combination treatment with statin and fasudil after subarachnoid hemorrhage in rabbit.Translational stroke research · 2013Article
- Nitric oxide in cerebral vasospasm: theories, measurement, and treatment.Neurology research international · 2013Article
- Cerebral vasospasm pharmacological treatment: an update.Neurology research international · 2013Article
- [Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: prevention, diagnostics and therapy].Der Nervenarzt · 2012Article
- [Aneurysmal subarachnoid hemorrhage].Der Anaesthesist · 2012Review
- Statins and anti-inflammatory therapies for subarachnoid hemorrhage.Current treatment options in neurology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins were shown to have neuroprotective effects, with reduced vasospasm and delayed ischemic deficits in statin-treated patients after aneurysmal subarachnoid hemorrhage in two small, randomized, controlled clinical trials published in 2005. This review consolidated data from available published studies evaluating statin treatment for subarachnoid hemorrhage. A literature search was conducted to identify original research studies published through October 2010 testing immediate treatment with a statin in statin-naïve patients following aneurysmal SAH. Six randomized controlled clinical trials and four observational studies were identified. Despite inconsistent results among studies, a meta-analysis of randomized controlled data showed a significant reduction in delayed ischemic deficits with statins. Effect on vasospasm was more difficult to determine, due to differences in definitions used among studies. Interpretations from observational studies were limited by the use of relatively small sample sizes, historical controls, and treatment variability.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.