ArticleJournal of genetic counseling2012
At-risk marriages after compulsory premarital testing and counseling for β-thalassemia and sickle cell disease in Saudi Arabia, 2005-2006.
Article in Journal of genetic counseling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 53 citations in OpenAlex.
- Reproductive Health CHOICES for Young Adults with Sickle Cell Disease or Trait: Randomized Controlled Trial Outcomes over Two Years.Journal of genetic counseling · 2016Trial
- EHA Recommendations for preconceptual and antenatal screening and prenatal diagnosis for hemoglobinopathies.HemaSphere · 2026Article
- Geneticization outside genetics' birthplace: ethical, legal and social implications in the Gulf Cooperation Council region.Frontiers in genetics · 2026Article
- Experiences and insights of thalassaemia carriers from an indigenous community in Sabah, Malaysia.Journal of community genetics · 2025Article
- Factors affecting marriage decisions among couples with sickle cell or beta-thalassemia traits.Journal of Taibah University Medical Sciences · 2025Article
- Haematologists as Genetic Counsellors for Haemoglobinopathies: Are They Prepared?Hematology reports · 2025Review
- Determinants of marital decision despite sickle cell status awareness: a mixed method study.BMC public health · 2025Article
- Knowledge, Attitudes, and Practices of the General Population Regarding Peripheral Blood Chromosomal Testing in the Premarital or Preconception Context.Molecular genetics & genomic medicine · 2025Article
- Health education to promote knowledge about sickle cell disease and newborn screening in pregnant women: a community-based pilot study using the healthy beginning initiative.BMC pregnancy and childbirth · 2024Article
- Awareness of sickle cell disease among nursing undergraduates in Farasan: Its interference with malaria.Journal of family medicine and primary care · 2024Article
- Knowledge and Attitudes of Secondary Schools students Towards Premarital Screening and Counseling in Taiz, Yemen.Journal of multidisciplinary healthcare · 2024Article
- Perception of consanguineous marriage among the qatari population.Frontiers in public health · 2023Article
- Assessment of Perceptions and Predictors Towards Consanguinity: A Cross-Sectional Study from Palestine.Journal of multidisciplinary healthcare · 2023Article
- Assessment of Factors Associated with the Effectiveness of Premarital Screening for Hemoglobinopathies in the South of Saudi Arabia.International journal of general medicine · 2021Article
- Socio-religious Prognosticators of Psychosocial Burden of Beta Thalassemia Major.Journal of religion and health · 2020Article
- Social and cultural influences on genetic screening programme acceptability: A mixed-methods study of the views of adults, carriers, and family members living with thalassemia in the UK.Journal of genetic counseling · 2020Article
- Haemoglobinopathies in India: estimates of blood requirements and treatment costs for the decade 2017-2026.Journal of community genetics · 2020Article
- Perception of premarital counseling among King Khalid University students.Journal of family medicine and primary care · 2019Article
- Quantifying the Levels of Knowledge, Attitude, and Practice Associated with Sickle Cell Disease and Premarital Genetic Counseling in 350 Saudi Adults.Advances in hematology · 2019Article
- Knowledge and attitude toward hemoglobinopathies premarital screening program among unmarried population in western Saudi Arabia.Saudi medical journal · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Results from a screening program for sickle cell disease and β-thalassemia suggest about 90% of couples in Saudi Arabia at risk of having affected children still decide to marry. This study determined the rate of at-risk marriages and identified several factors that may prevent at risk couples from marrying. The marriage status of 934 at-risk couples was determined from original screening program records in the Ministry of Health. Of 934 couples, 824 married (88.2%) and 110 (11.8%) did not. A case-controlled study was conducted on 104 couples who did not marry (cases) and 478 couples who did marry (controls) in order to assess relationships between various cultural and social factors and marriage decisions. In the case-controled study, 28.8% of couples (30/104) who did not marry (cases) knew their disease or carrier status before screening compared to 18% (86/478) of those who married (controls). Reasons couples gave for proceeding with marriage included: wedding plans could not be canceled, and fear of social stigma. Couples who did not marry reported being influenced by prior knowledge of their disease or carrier status and whether they or family members were affected. Approximately half of the cases and controls (n = 270, 46.4%) thought it best to undergo screening before proceeding with the engagement and wedding plans. Most couples received no advice to participate in genetic counseling services. Marriage decisions for the small number who received genetic counseling (n = 168, 27.6%) did not differ significantly from those that received no counseling. Recommendations are made for improving the effectiveness of this screening program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.