ArticleJournal of neuro-oncology2012
Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- The role of clinical factors and immunocheckpoint molecules in the prognosis of patients with supratentorial extraventricular ependymoma: a single-center retrospective study.Journal of cancer research and clinical oncology · 2021Trial
- A brief history of ependymoma.Neuro-oncology · 2026Review
- Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.Journal of Korean Neurosurgical Society · 2026Article
- Distinct relapse pattern across molecular ependymoma types.Neuro-oncology · 2025Article
- Radiotherapy dosing in intracranial ependymoma using the national cancer database.Journal of neuro-oncology · 2024Article
- Survival of pediatric patients with ependymoma in a tertiary cancer center in Rio de Janeiro, Brazil.Frontiers in oncology · 2024Article
- Review and update on pediatric ependymoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- The anatomy of neuroepithelial tumours.Brain : a journal of neurology · 2023Article
- Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru.Frontiers in oncology · 2023Article
- Ependymoma: Evaluation and Management Updates.Current oncology reports · 2022Review
- Prognostic Factors and Histopathological Features of Pediatric Intracranial Ependymomas: Nationwide Brain Tumor Registry-based Study of Japan.Neurologia medico-chirurgica · 2022Article
- Treatment and outcome of pediatric intracranial ependymoma after first relapse.Journal of neuro-oncology · 2022Article
- Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol.Frontiers in neurology · 2022Article
- Do We Need Radiotherapy in Grade II Ependymoma?Frontiers in oncology · 2022Article
- Polish Multi-Institutional Study of Children with Ependymoma-Clinical Practice Outcomes in the Light of Prospective Trials.Diagnostics (Basel, Switzerland) · 2021Article
- Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.Neurosurgical review · 2021Review
- Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas.Cancers · 2020Article
- Intraventricular neuroepithelial tumors: surgical outcome, technical considerations and review of literature.BMC cancer · 2020Observational
- Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma.Neuro-oncology · 2020Article
- Personalizing age-specific survival prediction and risk stratification in intracranial grade II/III ependymoma.Cancer medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Management of pediatric intracranial ependymomas poses a major challenge, and optimal treatment remains controversial. We sought to investigate the roles of surgery, radiation, and chemotherapy in a historical cohort. Thirty-nine children, age 21 or younger, with non-metastatic intracranial ependymomas were treated from 1972 to 2008. Median age was 8 years (range 0.2-19.1). Twenty-one patients (54%) underwent GTRs, and 18 (45%) underwent STRs. Twenty-six patients (67%) received upfront adjuvant RT (67%), and 14 (44%) received adjuvant chemotherapy. Twenty-four patients had disease recurrence and 12 died. Only one patient recurred after 5 years. Median PFS was 2.7 years and median OS was 20 years. Fifteen year PFS and OS were 30 and 67%. Adjuvant RT was associated with improved PFS (P = 0.045), and remained significant after adjusting for EOR (P = 0.04). Greater EOR trended towards prolonged survival, but did not reach statistical significance (P = 0.156). Of the patients that underwent GTR, the median PFS was 38 months for those treated with adjuvant RT versus 30 months for those that were not treated with RT. Of the patients that had STR, the median PFS for those treated with RT was 26.3 months versus 6.9 months for those were not treated with RT. In conclusion, for localized intracranial pediatric ependymomas, adjuvant RT is associated with improved PFS, even after adjusting for EOR. Our findings suggest the benefit of RT even in the presence of GTR. Future prospective studies with larger sample number are needed to validate our findings.
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