ArticleJournal of fluorescence2012
Synthesis of benzimidazoles containing pyrazole group and quantum chemistry calculation of their spectroscopic properties and electronic structure.
Article in Journal of fluorescence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Insights into the Antiparasitic Activity of Pyrazole-benzimidazole againstCurrent medicinal chemistry · 2025Article
- A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.Chemical communications (Cambridge, England) · 2014Article
- Synthesis and spectroscopic properties of novel fluorescent compounds containing bis-pyrazole ring.Journal of fluorescence · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five benzimidazole compounds containing pyrazole group were synthesized via one-step reaction of o-phenylenediamine and 1-arylpyrazole-4-carbaldehyde in ethanol under mild conditions. The composition and structure of resultant benzimidazole compounds were analyzed by means of elemental analysis, mass spectrometry, (1)H-nuclear magnetic resonance spectroscopy and X-ray single crystal diffraction. The ultraviolet-visible light spectra and fluorescent spectra of the products were measured. Their ground-state (S(0)) equilibrium geometries and vibrational frequencies were determined based on B3LYP method, and their first excited-state (S(1)) geometries were fully optimized based on 6-31G (d, p) basis set of TD-B3LYP method. Besides, the spectroscopic properties of the products were computed based on cc-pVTZ basis set of TD-B3LYP method and compared with corresponding experimental data. It has been found that benzimidazole compounds containing pyrazole group can be readily synthesized in a high yield via one-step reaction of o-phenylenediamine and 1-arylpyrazole-4-carbaldehyde in ethanol solvent. The fluorescence properties of the five synthesized compounds are closely related to their molecular structure; and their computed fluorescence spectra well correspond to their experimental values. Moreover, they have stable structure and strong fluorescence, showing potential application in time-resolved fluoroimmunoassay and DNA probe.
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