ArticlePloS one2011
A mismatch-based model for memory reconsolidation and extinction in attractor networks.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Assessing the translational feasibility of pharmacological drug memory reconsolidation blockade with memantine in quitting smokers.Psychopharmacology · 2015Trial
- Cannabidiol enhances consolidation of explicit fear extinction in humans.Psychopharmacology · 2013Trial
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans.Communications biology · 2020Article
- Article
- Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between.Frontiers in behavioral neuroscience · 2020Review
- Acute but Not Permanent Effects of Propranolol on Fear Memory Expression in Humans.Frontiers in human neuroscience · 2019Article
- A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers.Journal of visualized experiments : JoVE · 2018Article
- On the transition from reconsolidation to extinction of contextual fear memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The computational nature of memory modification.eLife · 2017Article
- The effects of cognitive reappraisal following retrieval-procedures designed to destabilize alcohol memories in high-risk drinkers.Psychopharmacology · 2016Article
- A Model of Synaptic Reconsolidation.Frontiers in neuroscience · 2016Article
- Rewriting the valuation and salience of alcohol-related stimuli via memory reconsolidation.Translational psychiatry · 2015Article
- Rescue of long-term memory after reconsolidation blockade.Nature communications · 2015Article
- Calcineurin inhibition blocks within-, but not between-session fear extinction in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- New automated procedure to assess context recognition memory in mice.Psychopharmacology · 2014Article
- Prediction error demarcates the transition from retrieval, to reconsolidation, to new learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus.Frontiers in behavioral neuroscience · 2014Article
- Modeling reconsolidation in kernel associative memory.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The processes of memory reconsolidation and extinction have received increasing attention in recent experimental research, as their potential clinical applications begin to be uncovered. A number of studies suggest that amnestic drugs injected after reexposure to a learning context can disrupt either of the two processes, depending on the behavioral protocol employed. Hypothesizing that reconsolidation represents updating of a memory trace in the hippocampus, while extinction represents formation of a new trace, we have built a neural network model in which either simple retrieval, reconsolidation or extinction of a stored attractor can occur upon contextual reexposure, depending on the similarity between the representations of the original learning and reexposure sessions. This is achieved by assuming that independent mechanisms mediate Hebbian-like synaptic strengthening and mismatch-driven labilization of synaptic changes, with protein synthesis inhibition preferentially affecting the former. Our framework provides a unified mechanistic explanation for experimental data showing (a) the effect of reexposure duration on the occurrence of reconsolidation or extinction and (b) the requirement of memory updating during reexposure to drive reconsolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.