ArticlePloS one2011
Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex.Communications biology · 2024Article
- Article
- MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size.eLife · 2023Article
- Article
- MicroRNA-Based Separation of Cortico-Fugal Projection Neuron-Like Cells Derived From Embryonic Stem Cells.Frontiers in neuroscience · 2019Article
- Decoding the ubiquitous role of microRNAs in neurogenesis.Molecular neurobiology · 2017Review
- MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.EMBO reports · 2017Article
- MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development.The EMBO journal · 2016Article
- Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development.Neural development · 2016Article
- Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.Cell reports · 2016Article
- Role of miRNA-9 in Brain Development.Journal of experimental neuroscience · 2016Review
- Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.NPJ aging and mechanisms of disease · 2016Review
- Radial glia, the keystone of the development of the hippocampal dentate gyrus.Molecular neurobiology · 2015Review
- MicroRNAs: Not "Fine-Tuners" but Key Regulators of Neuronal Development and Function.Frontiers in neurology · 2015Review
- Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.PloS one · 2015Article
- Control of cerebral size and thickness.Cellular and molecular life sciences : CMLS · 2014Review
- Convergent microRNA actions coordinate neocortical development.Cellular and molecular life sciences : CMLS · 2014Review
- Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway.Cell reports · 2014Article
- Growth and folding of the mammalian cerebral cortex: from molecules to malformations.Nature reviews. Neuroscience · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Early telencephalic development involves transformation of neuroepithelial stem cells into radial glia, which are themselves neuronal progenitors, around the time when the tissue begins to generate postmitotic neurons. To achieve this transformation, radial precursors express a specific combination of proteins. We investigate the hypothesis that micro RNAs regulate the ability of the early telencephalic progenitors to establish radial glia. We ablate functional Dicer, which is required for the generation of mature micro RNAs, by conditionally mutating the Dicer1 gene in the early embryonic telencephalon and analyse the molecular specification of radial glia as well as their progeny, namely postmitotic neurons and basal progenitors. Conditional mutation of Dicer1 from the telencephalon at around embryonic day 8 does not prevent morphological development of radial glia, but their expression of Nestin, Sox9, and ErbB2 is abnormally low. The population of basal progenitors, which are generated by the radial glia, is disorganised and expanded in Dicer1⁻/⁻ dorsal telencephalon. While the proportion of cells expressing markers of postmitotic neurons is unchanged, their laminar organisation in the telencephalic wall is disrupted suggesting a defect in radial glial guided migration. We found that the laminar disruption could not be accounted for by a reduction of the population of Cajal Retzius neurons. Together, our data suggest novel roles for micro RNAs during early development of progenitor cells in the embryonic telencephalon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.