ArticleLaboratory animal research2011
Difference in Resistance to Streptococcus pneumoniae Infection in Mice.
Article in Laboratory animal research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- By dawn or dusk-how circadian timing rewrites bacterial infection outcomes.FEBS letters · 2026Review
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- Cannabinoids and alcohol co-exposure modulate pathogen-induced pulmonary immune responses.Frontiers in immunology · 2025Article
- Neutrophil Recruitment in Pneumococcal Pneumonia.Frontiers in cellular and infection microbiology · 2022Review
- A Retro-orbital Sinus Injection Mouse Model to Study Early Events and Reorganization of the Astrocytic Network during Pneumococcal Meningitis.Bio-protocol · 2021Article
- Article
- Disruption of theVaccines · 2020Article
- ATF3 Stimulates IL-17A by Regulating Intracellular CaFrontiers in immunology · 2018Article
- Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection.Journal of innate immunity · 2017Article
- NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-γ Production.Journal of immunology research · 2015Article
- Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8⁺ T cell response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Characterization of inflammatory responses during intranasal colonization with Streptococcus pneumoniae.Journal of visualized experiments : JoVE · 2014Article
- E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae.Prostaglandins & other lipid mediators · 2012Article
- T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pneumoniae is a major pathogen that causes various diseases, including pneumonia and sepsis, as millions of people suffer from S. pneumoniae infection worldwide. To better understand the immune and inflammatory responses to S. pneumoniae, we produced murine models. To investigate the differences between intranasal and intratracheal infection, BALB/c mice were infected with S. pneumoniae D39 intranasally or intratracheally. Mice showed no significant differences in survival rates, body weight changes, and bacterial loads. To investigate resistance and susceptibility among mouse strains, BALB/c, C57BL/6J, tumor necrosis factor-α (TNF-α) knockout, and interleukin-10 (IL-10) knockout mice were infected with S. pneumoniae D39 via intranasal or intravenous routes. In this study, BALB/c and C57BL/6J mice were resistant, IL-10 knockout mice were intermediate, and TNF-α knokout mice were susceptible to S. pneumoniae infection. These data show that intranasal and intratracheal infection induced similar results after S. pneumoniae infection, and the genetic background of mice must be considered when studying S. pneumoniae infection in vivo.
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