ArticleProceedings of the National Academy of Sciences of the United States of America2011
Cytoskeletal actin networks in motile cells are critically self-organized systems synchronized by mechanical interactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Migratory responses in enucleated cells: The forces driving the locomotion movement of unicellular organisms.PNAS nexus · 2025Article
- Structure, motion, and multiscale search of traveling networks.Nature communications · 2025Article
- Systemic cellular migration: The forces driving the directed locomotion movement of cells.PNAS nexus · 2024Article
- Contact guidance as a consequence of coupled morphological evolution and motility of adherent cells.Biomechanics and modeling in mechanobiology · 2022Article
- Understanding cytoskeletal avalanches using mechanical stability analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality.Scientific reports · 2021Article
- Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration.Communications biology · 2020Article
- A continuum model for the growth of dendritic actin networks.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- DLITE Uses Cell-Cell Interface Movement to Better Infer Cell-Cell Tensions.Biophysical journal · 2019Article
- Growth and remodelling of living tissues: perspectives, challenges and opportunities.Journal of the Royal Society, Interface · 2019Review
- Quantifying dissipation in actomyosin networks.Interface focus · 2019Article
- Does self-organized criticality drive leading edge protrusion?Biophysical reviews · 2018Review
- In search of principles for a Theory of Organisms.Journal of biosciences · 2015Article
- Proteinquakes in the evolution of influenza virus hemagglutinin (A/H1N1) under opposing migration and vaccination pressures.BioMed research international · 2015Article
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- Ultrastructure of protrusive actin filament arrays.Current opinion in cell biology · 2013Review
- Crawling motility through the analysis of model locomotors: two case studies.The European physical journal. E, Soft matter · 2012Article
- The role of membrane stiffness and actin turnover on the force exerted by DRG lamellipodia.Biophysical journal · 2012Article
- Mesoscopic model of actin-based propulsion.PLoS computational biology · 2012Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing networks of actin fibers are able to organize into compact, stiff two-dimensional structures inside lamellipodia of crawling cells. We put forward the hypothesis that the growing actin network is a critically self-organized system, in which long-range mechanical stresses arising from the interaction with the plasma membrane provide the selective pressure leading to organization. We show that a simple model based only on this principle reproduces the stochastic nature of lamellipodia protrusion (growth periods alternating with fast retractions) and several of the features observed in experiments: a growth velocity initially insensitive to the external force; the capability of the network to organize its orientation; a load-history-dependent growth velocity. Our model predicts that the spectrum of the time series of the height of a growing lamellipodium decays with the inverse of the frequency. This behavior is a well-known signature of self-organized criticality and is confirmed by unique optical tweezer measurements performed in vivo on neuronal growth cones.
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