ArticleProceedings of the National Academy of Sciences of the United States of America2011
Nuclear membranes control symbiotic calcium signaling of legumes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
84 citing papers in PubMed, 223 citations in OpenAlex.
- Integrative Multi-Omics Analysis Reveals Transcriptomic and Metabolic Remodeling Associated with Enhanced Peanut Nodulation Under Arbuscular Mycorrhizal Fungal Inoculation and Calcium Application.Plants (Basel, Switzerland) · 2026Article
- Advances in Imaging of Plant CaBiomolecules · 2026Review
- Putting channels in their place: nucleoporins and symbiotic signaling in legumes.Plant physiology · 2026Article
- Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026Review
- ECLIPSE mediates selective degradation of inner nuclear membrane protein in plants.Journal of experimental botany · 2025Article
- Structural basis for the activity regulation of Medicago calcium channel CNGC15.Cell discovery · 2025Article
- Nutrient-dependent regulation of symbiotic nitrogen fixation in legumes.Horticulture research · 2025Article
- The BRUTUS iron sensor and E3 ligase facilitates soybean root nodulation by monoubiquitination of NSP1.Nature plants · 2025Article
- Ethylene promotes SMAX1 accumulation to inhibit arbuscular mycorrhiza symbiosis.Nature communications · 2025Article
- Investigating biological nitrogen fixation via single-cell transcriptomics.Journal of experimental botany · 2025Review
- Cellular calcium homeostasis and regulation of its dynamic perturbation.Quantitative plant biology · 2025Review
- A mitochondrial metalloprotease FtsH4 is required for symbiotic nitrogen fixation in Lotus japonicus nodules.Scientific reports · 2024Article
- Metal nutrition and transport in the process of symbiotic nitrogen fixation.Plant communications · 2024Review
- Laser Capture Microdissection Transcriptome Reveals Spatiotemporal Tissue Gene Expression Patterns ofMolecular plant-microbe interactions : MPMI · 2023Article
- Calcium in the Life Cycle of Legume Root Nodules.Indian journal of microbiology · 2023Review
- Physical model of the nuclear membrane permeability mechanism.Biophysical reviews · 2023Review
- Article
- Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security?PLoS biology · 2023Article
- NIN-at the heart of NItrogen-fixing Nodule symbiosis.Frontiers in plant science · 2023Review
- Signaling and Detoxification Strategies in Plant-Microbes Symbiosis under Heavy Metal Stress: A Mechanistic Understanding.Microorganisms · 2022Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Nuclear-associated oscillations in calcium act as a secondary messenger in the symbiotic signaling pathway of legumes. These are decoded by a nuclear-localized calcium and calmodulin-dependent protein kinase, the activation of which is sufficient to drive downstream responses. This implies that the calcium oscillations within the nucleus are the predominant signals for legume symbiosis. However, the mechanisms that allow targeted release of calcium in the nuclear region have not been defined. Here we show that symbiosis-induced calcium changes occur in both the nucleoplasm and the perinuclear cytoplasm and seem to originate from the nuclear membranes. Reaction diffusion simulations suggest that spike generation within the nucleoplasm is not possible through transmission of a calcium wave from the cytoplasm alone and that calcium is likely to be released across the inner nuclear membrane to allow nuclear calcium changes. In agreement with this, we found that the cation channel DMI1, which is essential for symbiotic calcium oscillations, is preferentially located on the inner nuclear membrane, implying an essential function for the inner nuclear membrane in symbiotic calcium signaling. Furthermore, a sarco/endoplasmic reticulum calcium ATPase (SERCA) essential for symbiotic calcium oscillations is targeted to the inner nuclear membrane, as well as the outer nuclear membrane and endoplasmic reticulum (ER). We propose that release of calcium across the inner nuclear membrane allows targeted release of the ER calcium store, and efficient reloading of this calcium store necessitates the capture of calcium from the nucleoplasm and nuclear-associated cytoplasm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.