ArticleInfection and immunity2011
Filifactor alocis has virulence attributes that can enhance its persistence under oxidative stress conditions and mediate invasion of epithelial cells by porphyromonas gingivalis.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 128 citations in OpenAlex.
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- Unveiling potential driver taxa in subgingival plaque and their roles in mediating periodontitis progression.Journal of oral microbiology · 2026Article
- Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases.Journal of oral microbiology · 2026Review
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- Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape.Frontiers in oral health · 2025Article
- Identification ofJournal of pharmacy & bioallied sciences · 2024Article
- Possible immunomodulatory role of Filifactor alocis through beta-defensin 2 in gingival keratinocytes.Clinical oral investigations · 2024Article
- Association ofDentistry journal · 2024Article
- Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to HMolecular oral microbiology · 2024Article
- The impact ofFrontiers in dental medicine · 2024Review
- Enhancement of innate immunity in gingival epithelial cells by vitamin D and HDAC inhibitors.Frontiers in oral health · 2024Article
- Pelvic infection caused by periodontitis: A case report.Case reports in women's health · 2023Article
- Whole Genome Sequencing and Phenotypic Analysis of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- A Local Desiccant Antimicrobial Agent as an Alternative to Adjunctive Antibiotics in the Treatment of Periodontitis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Characterization of FA1654: A putative DPS protein in Filifactor alocis.Molecular oral microbiology · 2023Article
- Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens.Journal of applied oral science : revista FOB · 2023Article
- The emerging oral pathogen, Filifactor alocis, extends the functional lifespan of human neutrophils.Molecular microbiology · 2022Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Filifactor alocis, a Gram-positive anaerobic rod, is one of the most abundant bacteria identified in the periodontal pockets of periodontitis patients. There is a gap in our understanding of its pathogenicity and ability to interact with other periodontal pathogens. To evaluate the virulence potential of F. alocis and its ability to interact with Porphyromonas gingivalis W83, several clinical isolates of F. alocis were characterized. F. alocis showed nongingipain protease and sialidase activities. In silico analysis revealed the molecular relatedness of several virulence factors from F. alocis and P. gingivalis. In contrast to P. gingivalis, F. alocis was relatively resistant to oxidative stress and its growth was stimulated under those conditions. Biofilm formation was significantly increased in coculture. There was an increase in adherence and invasion of epithelial cells in coculture compared with P. gingivalis or F. alocis monocultures. In those epithelial cells, endocytic vesicle-mediated internalization was observed only during coculture. The F. alocis clinical isolate had an increased invasive capacity in coculture with P. gingivalis compared to the ATCC 35896 strain. In addition, there was variation in the proteomes of the clinical isolates compared to the ATCC 35896 strain. Hypothetical proteins and those known to be important virulence factors in other bacteria were identified. These results indicate that F. alocis has virulence properties that may enhance its ability to survive and persist in the periodontal pocket and may play an important role in infection-induced periodontal disease.
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